Dapsone has been used successfully as adjuvant therapy for bullous pemphigoid (BP). The effectiveness of dapsone for this indication, however, remains controversial. We evaluated the effectiveness and adverse events of dapsone (1.0-1.5 mg/kg per day) in combination with oral methylprednisolone (tapering doses of 0.5 mg/kg per day) and topical clobetasol propionate (initially applied once daily ...

Background: Vulval lichen planus (VLP) is a debilitating, often treatment resistant condition, for which there is limited evidence-based guidance on assessment and management. Aim: To describe current management of women with VLP in the multi-disciplinary vulval dermatology clinic at the Royal Women’s Hospital (RWH), Melbourne, to compare this with reported practices in the literature and provi...

CASE REPORT A 94-year-old male patient presented with multiple vegetating and granulomatous nodules on the right groin and gluteal region in the recent one year (Fig. 1A). He was robust before without any other systemic diseases except oral erosion developed one week before he visited our clinic. Tentative diagnosis included cutaneous fungal infection, cutaneous T cell lymphoma, and vegetating ...

Background Lichen sclerosus most commonly affects the genital area. Contrarily to lichen planus, the involvement of the oral or vaginal mucosa is rare. Only four cases of vaginal lichen sclerosus have been described in the literature. Case report The authors report two cases of postmenopausal women with a history of vulvar pruritus and burning. Both presented with lesions of the vaginal mucos...

Objectives: To study the epidemiological distribution of disease lichen planus and its therapeutic management. Methods: A total 174 patients with a diagnosis between 2008 2017 at Portuguese public hospital were included in this retrospective study. The following data collected from clinical records: gender, age, topographic lesions, prescribed therapy (active substance, route, scheme administra...

A 16 years old female patient, affected by atopic dermatitis and rhinoconjunctivitis allergica since childhood, requested a dermatologic consultation for lesions which had appeared after 3 months of local treatment with clobethasole propionate. The histological analysis confirmed the diagnosis of dyshidrotic eczema and the microbiological smears demonstrated a significant infection with Staphyl...

Plasmoacanthoma and plasma cell cheilitis are rare disorders of obscure etiology characterized by a plasma cell infiltrate. An 80-year-old woman presented with a verrucous, fleshy, skin colored plaque over lips, gingiva, and the palate and painful swallowing for over a period of 6 months. Histopathology of the lesion showed dense infiltrate of plasma cells. The lesions resolved completely after...

Report of Cases Patient 1 Awoman in her 40s without other significant medical history presented in 2013with an8-month history of an exquisitely painful ulcer on the distal left lateral leg. She noted that the lesion began as “a small red bump” that she believed to be an insect bite. A physician at another institution performed an incision and drainage to treat a suspected abscess and prescribed...

Cleaning validation is required in the pharmaceutical field to avoid potential clinically significant synergistic interactions between pharmacologically active chemicals. A simple, sensitive and accurate HPLC method has been developed and validated for determination of Clobetasol Propionate residues on the surface of manufacturing equipement. Separation of Clobetasol Propionate and Related comp...