Software protection is an area of active research in which a variety of techniques have been developed to address the issue. Examples of such techniques include code obfuscation, software watermarking, and tamper detection. In this paper we propose a tamper resistance technique which provides both on and offline tamper detection. In our offline approach, the software dynamically detects tamperi...

In situ, cells of the musculoskeletal system reside within complex and often interconnected 3-D environments. Key to better understanding how 3-D tissue and cellular environments regulate musculoskeletal physiology, homeostasis, and health is the use of robust methodologies for directly visualizing cell-cell and cell-matrix architecture in situ. However, the use of standard optical imaging tech...

The debts’ clearing problem is about clearing all the debts in a group of n entities (persons, companies etc.) using a minimal number of money transaction operations. The problem is known to be NP-hard in the strong sense. As for many intractable problems, techniques from the field of artificial intelligence are useful in finding solutions close to optimum for large inputs. An evolutionary algo...

In this article, we discuss the optical immersion method based on refractive index matching of scatterers (e.g., collagen, elastin fibers, cells and cell compartments) and the ground material (interstitial fluid and/or cytoplasm) of tissue and blood under the action of exogenous optical clearing agents. We analyze the optical clearing of fibrous and cell-structured tissues and blood from the po...

A possible relationship may exist between the concentration of heparin-activated plasma clearing factor and alterations in lipid metabolism associated with advancing age, atherosclerosis, and other diseases. To test this hypothesis, 121 men were evaluated in the development and application of a standardized in vitro method for the determination of clearing factor response to minimal heparin sti...

We study algorithms for combinatorial market design problems, where a set of heterogeneous and indivisible objects are priced and sold to potential buyers subject to equilibrium constraints. Extending the CWE notion introduced by Feldman et al. [STOC 2013], we introduce the concept of a Market-Clearing Combinatorial Walrasian Equilibium (MC-CWE) as a natural relaxation of the classical Walrasia...

Multiphoton microscopy of intrinsic fluorescence and second harmonic generation (SHG) of whole mouse organs is made possible by optically clearing the organ before imaging.(1,2) However, for organs that contain fluorescent proteins such as GFP and YFP, optical clearing protocols that use methanol dehydration and clear using benzyl alcohol:benzyl benzoate (BABB) while unprotected from light(3) d...

Tissue optical clearing technique shows a great potential for neural imaging with high resolution, especially for connectomics in brain. The passive clarity technique (PACT) is a relative simple clearing method based on incubation, which has a great advantage on tissue transparency, fluorescence preservation and immunostaining compatibility for imaging tissue blocks. However, this method suffer...

To carry out a genetic analysis of the degradation and utilization of chitin by Serratia marcescens 2170, various Tn5 insertion mutants with characteristic defects in chitinase production were isolated and partially characterized. Prior to the isolation of the mutants, proteins secreted into culture medium in the presence of chitin were analyzed. Four chitinases, A, B, C1, and C2, among other p...

It was recently shown in this laboratory (1) that in idiopathic hyperlipemia the elimination of lipids from the blood stream following an intravenous infusion of a fat emulsion is considerably delayed, indicating a defect of the lipemiaclearing mechanism in these patients. It was then found that the clearing activity present in the serum of normal human subjects who have received heparin was in...