alpha(1)-Adrenoceptor antagonists are the mainstay of medical treatment of male voiding dysfunction which typically is attributed to benign prostatic hyperplasia. While original concepts have assumed that they relieve voiding dysfunction by relaxing prostatic smooth muscle, newer data indicate that their therapeutic effects at least partly occur independent of prostatic relaxation, perhaps invo...

BACKGROUND Stress echocardiography is a valuable tool for the noninvasive diagnosis of ischemic heart disease. Despite its widely use in the clinical practice, safety and side effects profile have never been evaluated in Moroccans. THE AIM To assess the safety and tolerability of the two stress echo modalities in Moroccans. METHODS The study was made by 311 patients with known or suspected ...

Fingolimod is a selective immunosuppressive agent approved worldwide for the treatment of relapsing-remitting multiple sclerosis (MS), a chronic and potentially disabling neurological condition. Randomized double-blind clinical trials have shown that fingolimod significantly reduces relapse rate and ameliorates a number of brain MRI measures, including cerebral atrophy, compared to both placebo...

The aim of this multi-center, open-label, randomized, parallel-group trial was to compare the efficacy of rosuvastatin with that of simvastatin in achieving the 1998 European Atherosclerosis Society (EAS) lipid treatment goals. 504 patients (> or =18 years) with primary hypercholesterolemia and a 10-year cardiovascular (CV) risk >20% or history of coronary heart disease (CHD) or other establish...

efficacy and tolerability of bowel preparation for afternoon colonoscopy. Study subjects were randomized to one of two therapeutic dosing strategies: the same-day two sachets of picosulfate group (n=97, group A) vs. conventional split-dose 4 L polyethylene glycol (PEG) group (n=99, group B). The primary endpoint was bowel preparation success assessed by using the Ottawa scale. Patients’ tolerab...

Objective: To observe tolerability-related aspects of drug-utilization and outcome of olanzapine (Zyprexa®) treatment in daily practice in patients pre-treated with other antipsychotics. Method: Outpatients with schizophrenia (ICD-10) or other psychiatric disorders pre-treated with antipsychotic medication other than olanzapine participated in this noninterventional drug utilization observation...

OBJECTIVE The objective of this study was to analyze the effectiveness and long-term tolerability of adjuvant lacosamide (LCM) in a multicenter cohort. We aim to assess outcomes of LCM-containing antiepileptic drug (AED) combinations based upon 'mechanism of action' (MoA) and patient's clinical features. METHODS Consecutive patients commenced on LCM, with focal epilepsy were identified from t...

Background and Hypothesis:Glaucoma is a group of progressive optic nerve neuropathies that commonly cause vision loss or blindness. The most prevalent these known as primary open-angle glaucoma. POAG caused by increased intraocular pressure (IOP) in the anterior chamber eye, due to resistance outflow aqueous humor. Netarsudil recently developed novel medication for lowering pressure. aim this s...

objectives: saffron is the stigma of crocus sativus l., which has the potentials to play a role in the treatment of many diseases. although many researches are now going on this precious spice, there are few data on saffron safety in human, especially in patients with chronic mental illnesses. this study aimed to evaluate the short-term safety and tolerability of both saffron and crocin (its ma...

Objective. To evaluate the efficacy and tolerability of a fixed-dose combination of dexketoprofen and dicyclomine (DXD) injection in patients with acute renal colic. Patients and Methods. Two hundred and seventeen patients were randomized to receive either DXD (n = 109) or fixed-dose combination of diclofenac and dicyclomine injection (DLD; n = 108), intramuscularly. Pain intensity (PI) was sel...