The biological activities of tocotrienols are receiving increasing attention. Herein, we report the efficacy of a mixed-tocotrienol diet against prostate tumorigenesis in the transgenic adenocarcinoma mouse prostate (TRAMP) mouse model. Male TRAMP mice, 8 wk old, were fed 0.1%, 0.3%, or 1% mixed tocotrienols in AIN-76A diet up to 24 wk old. Likewise, a positive control group consisting of male ...

Vitamin E comprises 8 functionally unique isoforms and may be a suitable candidate for the adjuvant treatment of prostate cancer. In this study, we examined the ability of 2 vitamin E isoforms [α-tocotrienol (γ-TT) and δ-tocotrienol (δ-TT)] and 4 synthetic derivatives [γ- and δ-tocotrienol succinate (γ-TS, δ-TS), α-tocopheryl polyethylene glycol succinate (TPGS), and α-tocopheryl polyethylene g...

BACKGROUND Tocotrienols (T3) and tocopherols (T), both members of the natural vitamin E family have unique biological functions in humans. T3 are detected in circulating human plasma and lipoproteins, although at concentrations significantly lower than α-tocopherol (α-T). T3, especially α-T3 is known to be neuropotective at nanomolar concentrations and this study evaluated the postprandial fate...

This paper deals with a goal-oriented agent model called Goal Decomposition Tree (GDT) allowing both to specify and validate the behaviour of an agent. This work takes place in a global framework whose goal is to define a process allowing to start from a problem specification to obtain a validated implementation of a corresponding MAS. The GDT model has been used to specify a prey-predator syst...

During the latest years, a number of studies have confirmed the benefits of perioperative haemodynamic optimisation on surgical mortality and postoperative complication rate. This process requires the use of advanced haemodynamic monitoring with the purpose of guiding therapies to reach predefined goals. This review aim to present recent evidence on perioperative goal directed therapy (GDT), wi...

Palm oil contains vitamin E which comprises two structurally similar compounds namely tocopherols and tocotrienols. For many years considered the best therapy in curing disease, but recent research advances, tocotrienol has been widely used as a powerful several diseases, including cancer. We prepared this article to review analyze role of tocotrienols from palm anticancer molecules their mecha...

Diseases that occur during the transition period are exacerbated when cows unable to cope with an increased pro-oxidant load results in oxidative stress. Dairy cattle routinely supplemented vitamin E analog ?-tocopherol mitigate severity of Nonetheless, stress remains a disease predisposing condition for many dairy cattle. A better method optimizing antioxidant functions is needed. ?-Tocopherol...

It is often valuable to compare protein structures to determine how similar they are. Structure comparison methods such as RMSD and GDT-TS are based solely on fixed geometry and do not take into account the intrinsic flexibility or energy landscape of the protein. We propose a method, which we call FlexE, that is based on a simple elastic network model and uses the deformation energy as measure...

In this work, we develop a fully automated method for the quality assessment prediction of protein structural models generated by structure prediction approaches such as fold recognition servers, or ab initio methods. The approach is based on fragment comparisons and a consensus C(alpha) contact potential derived from the set of models to be assessed and was tested on CASP7 server models. The a...