The carbohydrate antigens Tn and sialyl-Tn (STn) are expressed in most carcinomas and usually absent in healthy tissues. These antigens have been correlated with cancer progression and poor prognosis, and associated with immunosuppressive microenvironment. Presently they are used in clinical trials as therapeutic vaccination, but with limited success due to their low immunogenicity. Alternative...

Anterior keratectomy (AKE) was done on rabbits, and the appearance of immunohistochemically demonstrable tenascin (TN) or cellular fibronectin (cFN) was studied at different times (5 min to 14 months) after the operation. The substance TN was first observed 12 hr after wounding in the posterior stroma; cFN appeared with the same localization 12 hr later. During postoperative week 1, both TN and...

1. Materials Science & Technology Div., Oak Ridge National Laboratory, Oak Ridge TN 37831, U.S.A. 2. Dept. de Física Aplicada III & Instituto Pluridisciplinar, Univ. Complutense, Madrid, 28040 Spain. 3. Instituto de Ciencia de Materiales de Barcelona, ICMAB-CSIC, Bellaterra, 08193 Spain. 4. Dept. of Physics & Astronomy, Vanderbilt University. Nashville, TN 37235, U.S.A. 5. Dept. of Material Sci...

Infections caused by multidrug-resistant bacteria have been on the rise. This important issue presents a great challenge to the healthcare system and creates an urgent need for alternative therapeutic agents. As a potential solution to this problem, antimicrobial peptides (AMPs) have attracted increasing attention due to their broad spectrum of targeted microbes. However, most AMPs are expensiv...

If n = 2, then the set j£ is closely related to the Fibonacci sequence; specifically, t GT2 iff the 7 term of the Fibonacci sequence is odd. We ask, for each w, which numbers are uniquely expressible as the sum of two distinct elements of Tn. In general, for any given w, one can determine exactly which numbers are uniquely expressible. If w = 2, it is easy to see that there are five such number...

Let Tn be the Teichmüller space of flat metrics on the n-dimensional torus T and identify SLn Z with the corresponding mapping class group. We prove that the subset Y consisting of those points at which the systoles generate π1(T) is, for n ≥ 5, not contractible. In particular, Y is not a SLn Z-equivariant deformation retract of Tn. For n ≥ 2 let Tn be the Teichmüller space of flat metrics with...

We quantified dry and wet deposition of dust, nitrogen, and phosphorus over the southwest Mediterranean region (Sierra Nevada, Spain) and assessed its effects on the nutrient status and the chlorophyll a (Chl a) concentration in two high mountain lakes. Atmospheric deposition of particulate matter (PM) and total phosphorus (TP) were mainly associated with dryfall and showed a seasonal pattern s...