When a replicative DNA polymerase stalls upon encountering a photoproduct on the template strand, it is relieved by other low-processivity polymerase(s), which insert nucleotide(s) opposite the lesion. Using an alkaline sucrose density gradient sedimentation technique, we previously classified this process termed UV-induced translesion replication (UV-TLS) into two types. In human cancer cells ...

PURPOSE Flavopiridol, the first clinically evaluated cyclin-dependent kinase inhibitor, shows activity in patients with refractory chronic lymphocytic leukemia, but prevalent and unpredictable tumor lysis syndrome (TLS) presents a major barrier to its broad clinical use. The purpose of this study was to investigate the relationships between pretreatment risk factors, drug pharmacokinetics, and ...

Secure Session Layer (SSL) and Transport Layer Security (TLS) are the two secure layer protocols in all of current web applications on a network. This paper focuses on SSL, TLS and how handshaking mechanism has been implemented in both SSL and TLS. Further, describes about the generation of keys and certificates.

The role of tertiary lymphoid structures (TLS) in cancer has recently been illustrated and revisited using mouse models. Joshi et al. describe regulatory T (Treg) cell infiltration and functional heterogeneity of TLS in lung tumors. Finkin et al. report that inflammation-associated TLS serve as niche for tumor progenitor cells, which may lead to recurrence in hepatocellular-carcinoma.

Tumor lysis syndrome (TLS) is a life-threatening oncological emergency that frequently occurs in patients with hematological malignancies. It is becoming more common in patients with solid tumors because of advances in molecular targeted therapies. Recombinant urate oxidase (rUO) is effective at preventing and treating hyperuricemia, but clinicians who treat adult patients with solid tumors are...

We present a security analysis of the complete TLS protocol in the Universal Composable security framework. This analysis evaluates the composition of key exchange functionalities realized by the TLS handshake with the message transmission of the TLS record layer to emulate secure communication sessions and is based on the adaption of the secure channel model from Canetti and Krawczyk to the se...

This document describes the use of Transport Layer Security (TLS) to provide privacy for DNS. Encryption provided by TLS eliminates opportunities for eavesdropping and on-path tampering with DNS queries in the network, such as discussed in RFC 7626. In addition, this document specifies two usage profiles for DNS over TLS and provides advice on performance considerations to minimize overhead fro...

We analyze the security of the TLS Record Protocol, a MACthen-Encode-then-Encrypt (MEE) scheme whose design targets confidentiality and integrity for application layer communications on the Internet. Our main results are twofold. First, we give a new distinguishing attack against TLS when variable length padding and short (truncated) MACs are used. This combination will arise when standardized ...

The TLS protocol has been a subject of studies, analyses and verification attempts over the years, but a recently discovered attack against the key renegotiation in the TLS protocol underlined the need to more thoroughly study the key renegotiation phase and focus on aspects not investigated before. We study the key renegotiation phase of the TLS protocol and use formal models for automatic ver...

Tertiary lymphoid structures (TLS) are ectopic lymphoid aggregates that reflect lymphoid neogenesis occurring in tissues at sites of inflammation. They are detected in tumors where they orchestrate local and systemic anti-tumor responses. A correlation has been found between high densities of TLS and prolonged patient's survival in more than 10 different types of cancer. TLS can be regulated by...