نتایج جستجو برای: tlr4 gene

تعداد نتایج: 1150600  

2009
Yuri Asukata Masao Ota Akira Meguro Yoshihiko Katsuyama Mami Ishihara Kenichi Namba Nobuyoshi Kitaichi Shin-ichiro Morimoto Toshikatsu Kaburaki Yasutaka Ando Shinobu Takenaka Hidetoshi Inoko Shigeaki Ohno Nobuhisa Mizuki

PURPOSE Toll-like receptors (TLRs) are pattern-recognition receptors that play an important role in innate and adaptive immune responses to microbial pathogens. Among TLRs, TLR4 recognizes lipopolysaccharides of Gram-negative bacteria. Genetic polymorphisms within the TLR4 gene have been reported to be associated with various inflammatory diseases; therefore, TLR4 appears to be a susceptibility...

Journal: :Infection and immunity 2003
Gary Leveque Vincenzo Forgetta Shaun Morroll Adrian L Smith Nat Bumstead Paul Barrow J C Loredo-Osti Kenneth Morgan Danielle Malo

Toll-like receptor 4 (TLR4) is part of a group of evolutionarily conserved pattern recognition receptors involved in the activation of the immune system in response to various pathogens and in the innate defense against infection. We describe here the cloning and characterization of the avian orthologue of mammalian TLR4. Chicken TLR4 encodes a 843-amino-acid protein that contains a leucine-ric...

Journal: :Infection and immunity 2005
Laura A Kerepesi Ofra Leon Sarah Lustigman David Abraham

Toll-like receptor 4 (TLR4) has been shown to be important for the induction of Th2-dependent immune responses in mice. Protective immunity against larval Onchocerca volvulus in mice depends on the development of a Th2 immune response mediated by both interleukin-4 (IL-4) and IL-5. In addition, O. volvulus contains the rickettsial endosymbiont Wolbachia, which has molecules with lipopolysacchar...

Journal: :The American journal of pathology 2006
Ilo Jou Jee Hoon Lee Soo Young Park Hee Jung Yoon Eun-Hye Joe Eun Jung Park

Gangliosides participate in various cellular events of the central nervous system and have been closely implicated in many neuronal diseases. However, the precise molecular mechanisms underlying the pathological activity of gangliosides are poorly understood. Here we report that toll-like receptor 4 (TLR4) may mediate the ganglioside-triggered inflammation in glia, brain resident immune cells. ...

Journal: :Arteriosclerosis, thrombosis, and vascular biology 2011
Jacco C Karper Margreet R de Vries Ben T van den Brand Imo E Hoefer Jens W Fischer J Wouter Jukema Hans W M Niessen Paul H A Quax

OBJECTIVE The goal of this study was to explore the role of Toll-like receptor 4 (TLR4) in vein graft remodeling and disease. METHODS AND RESULTS First, expression of TLR4 was analyzed in freshly isolated human saphenous veins (huSV), in freshly isolated huSV ex vivo perfused in an extracorporeal circulation, or in huSV used as coronary vein grafts. Marked induction of focal TLR4 expression w...

Journal: :PeerJ 2016
Axel Schoeniger Herbert Fuhrmann Julia Schumann

It is well known that PUFA impede the LPS-mediated activation of the transcription factor NFkappaB. However, the underlying mode of action has not been clarified yet. To address this issue in a comprehensive approach, we used the monocyte/macrophage cell line RAW264.7 to investigate the consequences of a PUFA supplementation on the TLR4 pathway with a focus on (i) the gene expression of TLR4 it...

Journal: :American journal of physiology. Gastrointestinal and liver physiology 2015
Bettina M Buchholz Richard A Shapiro Yoram Vodovotz Timothy R Billiar Chhinder P Sodhi David J Hackam Anthony J Bauer

Myocytes are nonhemopoietic in origin and functionally essential in generating gastrointestinal motility. In endotoxemia, a rapid-onset nonhemopoietic mechanism potently triggers early ileus in a Toll-like receptor 4 (TLR4)/myeloid differentiation primary response gene 88 (MyD88)-dependent manner. Moreover, synergistically with hemopoietic cells, nonhemopoietic cells escalate late ileus via an ...

Journal: :Journal of the American Society of Nephrology : JASN 2006
Gunter Wolf Jürgen Bohlender Tzvetanka Bondeva Thierry Roger Friedrich Thaiss Ulrich O Wenzel

Angiotensin II (AngII) mediates proinflammatory properties by activating NF-kappaB transcription factor nuclear translocation and inducing the expression of chemokines. For examination of whether AngII modulates the expression of Toll-like receptor 4 (TLR4), a key element of the innate immune system that senses LPS, mouse mesangial cells (MMC) were treated with AngII. AngII upregulated TLR4 mRN...

Journal: :Journal of research in veterinary medicine 2023

Increasing environmental temperatures due to climate change adversely affect livestock welfare and health. Moreover, increase the distribution survival of parasites infectious agents. Livestock diseases that cause significant economic losses are a worldwide concern. Toll-like receptor 4 (TLR4) is an ideal marker gene candidate, its critical role it plays in initiating immune response against pa...

Background: Toll like receptors play a major role in immune responses against Leishmania parasites. Objective: To evaluate the efficacy of vaccination with live attenuated L. major and TLR4 agonist in protection against L. major infection. Methods: Attenuated L. major was prepared by continuous sub-culturing of the parasite. A total of 90 mice were assigned to 9 groups including 6 groups of BAL...

نمودار تعداد نتایج جستجو در هر سال

با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید