PURPOSE The aim of this retrospective study was to assess the utility of a voxel-based analysis (VBA) method for (201)Tl SPECT in glioma, compared to conventional ROI analysis. METHODS We recruited 24 patients with glioma (high-grade 15; low-grade 9), for whom pre-operative (201)Tl SPECT and MRI were performed. SPECT images were coregistered with MRI. The uptake ratio (UR) images of tumor to ...

n engl j med 367;10 nejm.org september 6, 2012 885 of disorders, some of which can be treated (e.g., severe depression or effects of medications) but others of which may signal the development of incurable dementias, such as Alzheimer’s disease. For these reasons, the development and improvement of diagnostic procedures — and neuroimaging procedures, in particular — that aid in characterizing c...

Key words: lung metastases; parathyroid carcinoma; nodules with calcification. A Tl-201 and Tc-99m subtraction parathyroid scan revealed hot spots in the parathyroidectomy; tertiary hyperparathyroidism upper poles of both thyroid lobes. Serum aluminum concentrations were within the normal range (pre-DFO 6.9 mg/dl, post-DFO 9.4 mg/dl). Based on these

A 58-year-old man, who had biopsy-proven cardiac sarcoidosis, underwent TI-201 and I-123 MIBG cardiac scintigraphy. Although no perfusion defect was identified by Tl-201, mild heterogeneity of I-123 MIBG uptake was present in the myocardium. The denervated but viable myocardium was demonstrated in the heart with sarcoidosis. Cardiac sympathetic nerve function was impaired in cardiac sarcoidosis...

The role of various radionuclide investigations, including parathyroid scintigraphy, bone scintigraphy and serum parathormone estimations in the diagnosis of primary hyperparathyroidism is reviewed briefly. The initial experience with the dual isotope (Tl-201; Tc-99m) subtraction scintigraphy for the preoperative localization of parathyroid adenomas is presented (JPMA 37 : 237, 1987).

For transmission computed tomography (TCT) systems using a centered transmission source with a fan-beam collimator, the transmission projection data are truncated. To achieve sufficiently large imaging field of view (FOV), we have designed the combination of an asymmetric fan-beam (AsF) collimator and a small uncollimated sheet-source for TCT, and implemented AsF sampling on a two-head SPECT sy...

OBJECTIVES The aim of this study was to assess the prognostic value of the amount of perfusion-metabolic mismatch in revascularized patients with left ventricular (LV) dysfunction by means of Thallium (Tl)-201 and BMIPP imaging. METHODS Seventy-six patients with LV dysfunction and coronary artery disease underwent Tl-201 and BMIPP imaging. They were revascularized with either coronary artery ...

OBJECTIVE The aim of this study was to investigate the most robust predictor of myocardial viability among stress/rest reversibility (coronary flow reserve [CFR] impairment), (201)Tl perfusion status at rest, (201)Tl 24 hours redistribution and systolic wall thickening of (99m)Tc-methoxyisobutylisonitrile using a dual isotope gated myocardial perfusion single-photon emission computed tomography...