Lamotrigine (LMG) is an Antiepileptic drug which is widely used in epilepsy. It is also used in simple and complex partial seizures and secondary generalized tonic-clonic seizures. It is poorly water soluble drug (0.17mg/ml at 25 0 C). Thus, in the work under taken, an attempt was made to enhance the water solubility by complexation with β-cyclodextrin (1:5 molar ratios). The mouth dissolving t...

Recently, fast dissolving films are gaining interest as an alternative of fast dissolving tablets. The films are designed to dissolve upon contact with a wet surface, such as the tongue, within a few seconds, meaning the consumer can take the product without need for additional liquid. This convenience provides both a marketing advantage and increased patient compliance. As the drug is directly...

L( + )-Arginine hydrochloride was obtained from the Sigma Chemical Co., St Louis, Mo., U.S.A. The Arlco jackbean meal used in the preparation of urease was supplied by Hopkin and Williams Ltd., Chadwell Heath, Essex. The 'manganese-maleate solution' used in the preparation of arginase was made by dissolving 8-9 g. of MnSO4,4H20 and 1-8 g. of disodium maleate in glassdistilled water and making t...

Membrane distillation can desalinate seawater using low-grade heat energy or solar heat, but it has limited mass fluxes and membrane fouling issues. Glass membranes with integrated arrays of nanospiked microchannels and a narrow pore size distribution are made through a process that involves glass fiber drawing, dissolving template material from microchannels and differential chemical etching. ...

Microneedles were first conceptualized for drug delivery many decades ago, overcoming the shortages and preserving the advantages of hypodermic needle and conventional transdermal drug-delivery systems to some extent. Dissolving and biodegradable microneedle technologies have been used for transdermal sustained deliveries of different drugs and vaccines. This review describes microneedle geomet...

Plasminogen activators are enzymes found in all vertebrate species investigated so far. Their physiological function is the generation of localized proteolysis in the context of tissue remodeling, wound healing and neuronal plasticity. The common vampire bat (Desmodus rotundus) is a New World species that feeds exclusively on blood. Its saliva contains highly potent plasminogen activators, spec...

Highly porous poly (ϵ-caprolactone) microfiber scaffolds can be fabricated using electrospinning for tissue engineering applications. Melt electrospinning produces such scaffolds by direct deposition of a polymer melt instead of dissolving the polymer in a solvent as performed during solution electrospinning. The objective of this study was to investigate the significant parameters associated w...