Abstract Background Systemic sclerosis (SSc) is an autoimmune disease associated with widespread vasculopathy and progressive fibrosis of the skin internal organs. Cardiac involvement frequent, usually subclinical may involve all wall layers. Myocardial remodelling leads to electromechanical imparity, increasing vulnerability atrial fibrillation (AF). Unfortunately, little known about how long ...

We introduce a high-dimensional factor model with time-varying loadings. cover both stationary and nonstationary factors to increase the possibilities of applications. propose an estimation procedure based on two stages. First, we estimate common by principal components. In second step, considering estimated as observed, loadings are iterative generalized least squares using wavelet functions. ...