Zizyphus spina-christi (Rhamnaceae) grows wild in tropical Africa and Asia and can be domesticated. It has folkloric usage in pain related ailments throughout these regions. In view of the claimed therapeutic potentials, investigation of the plant’s root bark was initiated in our laboratory. The plant material was first sequentially extracted with hexane, chloroform, ethylacetate and methanol, ...

Recently, vast studies have been focused on the antinociceptive and anesthetic effects of α2 adrenergic receptors, using specific drugs such as medetomidine and dexmedetomidine. In the present study, we tried to assess the peripheral and central effects of dexmedetomidine in phasic and tonic pain, on rats, using tail flick and formalin tests. Dexmedetomidine, administered intraperitoneally (25,...

BACKGROUND Artemisia macrocephala Jacquem (A. macrocephala), locally known as "Tarkha", is a perennial plant found abundantly in northern areas of Pakistan. It is widely used in traditional medicine to treat fever, pain, gastrointestinal disorders and diabetes. Till date, no published studies are available regarding the in-vivo antinociceptive potential of the crude extract and sub-fractions fr...

Tail flick test in rats and acetic acid induced writhing in mice were employed to study the antinociceptive activity of ethanolic leaf extract of Vitex-negundo (VN) (100, 250 and 500 mg/kg, p.o). The effect was compared with meperidine (40 mg/kg, sc) in tail flick method and aspirin (50 mg/kg, p.o) in writhing test as a standard control respectively. An interaction with naloxone hydrochloride w...

conclusions our findings suggest that the analgesic effect of hrcle may be mediated via both peripheral and central mechanisms. the presence of flavonoids might be responsible for the anti-nociceptive activity of this plant. results hrcle significantly inhibited the number of contractions induced by acetic acid in the writhing test at all doses, while anti-nociceptive activity was only shown at ...

introduction: hyperalgesia is considered as one of the marked signs of subchronic diabetes mellitus in patients that could affect their lifestyle. this study was designed to investigate the anti-nociceptive effect of chronic administration of quercetin in streptozotocin (stz)-diabetic rats using formalin and hot tail immersion tests. methods: rats were divided into control, control or diabetic ...

Synadenium umbellatum Pax., popularly known in Brazil as "cola-nota," "avelós," "cancerola," and "milagrosa", is a plant species used in folk medicine for the treatment of inflammation, pain, and several diseases. This study aimed to investigate the antinociceptive and anti-inflammatory activities of the ethanolic extract from Synadenium umbellatum Pax. leaves (EES) and its hexane (HF), chlorof...

BACKGROUND The drive toward the use of medicinal plants has been increasing in recent years. They have few side effects and a large variety of efficient components. OBJECTIVES This study was designed to investigate the analgesic effects of hydroalcoholic Rhus coriaria leaf extract (HRCLE) in a rat model. MATERIALS AND METHODS A total of 42 adult male rats were divided into seven groups: a c...

Abstract Introduction: The aim of this study was to investigate the antinociceptive and antiinflammatory effects of Teucrium hyrcanicum aqueous extract in male mice and rats. Methods: To assess the antiinflammatory effect, we used carrageenan- and dextran-induced paw oedema and for determination of the antinociceptive effect, acetic acid-induced writhing, tail flick and formalin pain tests ...

It has been reported that morphine tolerance does not develop in the presence of chronic pain. Therefore, this study was conducted to find out whether chronic inflammatory pain is able to eliminate or attenuate the developed tolerance to analgesic effect of morphine and also to investigate the role of lumbar spinal cord as a candidate site for this interaction. Tolerance was induced in adult ma...