Antithrombotic management of patients with atrial fibrillation (AF) undergoing coronary stenting is complicated by the need for anticoagulant therapy for stroke prevention and dual antiplatelet therapy for prevention of stent thrombosis and coronary events. Triple antithrombotic therapy, typically comprising warfarin, aspirin, and clopidogrel, is associated with a high risk of bleeding. A modes...

BACKGROUND Data on pediatric antiphospholipid syndrome (APS) are very sparse. OBJECTIVES To describe the main clinical characteristics, laboratory data and complications of pediatric APS patients, and to analyze the differences between primary APS and APS associated with systemic lupus erythematosus (SLE). METHODS We retrospectively reviewed clinical and laboratory data of 32 children at th...

The case of a patient admitted with thrombotic thrombocytopenic purpura nine years after developing systemic lupus erythematosus (SLE) is reported. Thrombotic thrombocytopenic purpura associated with SLE has been described on other occasions, but in most patients the diagnosis of SLE precedes that of thrombotic thrombocytopenic purpura. The unusual sequence and the chronological separation of t...

Thrombophilia traditionally refers to rare inherited defects leading to enhanced coagulation, especially of the venous system. In recent years, a broader search for genetic polymorphisms of prothrombotic genes has been carried out to determine the relative impact on venous and arterial thrombosis. The bulk of evidence is drawn from numerous, often small, heterogeneous, case control association ...

1 Ridolfi RL, Bell WR. Thrombotic thrombocytopenic purpura. Report of 25 cases and review of the literature. Medicine 1981; 60: 413-28. 2 Bell Wr, Braine HG, Ness PM, Kuckler TS. Improved survival in thrombotic thrombocytopenic purpura-hemolytic uremic syndrome: clinical experience in 108 patients N Engl J Med 1991; 325: 398-403. 3 Harrison CN, Lawrie AS, Iqbal A, Hunter A, Machin SJ. Plasma ex...

UNLABELLED Acute myocardial infarction is usually caused by rupture of an atheromatous plaque in the coronary arteries. For patients without risk factors of atherosclerosis, other causes should be considered. We report on a 47-year-old woman with acute myocardial infarction but no cardiovascular risk factors, which was followed by deep vein thrombosis one week after recovery from acute myocardi...

Myocardial infarction in experimental animals lhas been successfully produced by ligating coronary artery branclhes(l), by injecting obstructing materials into the coronary vessels themselves(2), by external compression(3), and by intravascular electrocoagulation(4). Also, in rats Tlhomas an(l Hartroft were able by dietary means to procluce coronary thrombosis associated witlh myocardial necros...

TOPIC: Critical Care TYPE: Medical Student/Resident Case Reports INTRODUCTION: Thrombotic thrombocytopenic purpura (TTP) is an acquired or inherited condition characterized by platelet aggregation and thrombosis due to accumulation of von Willebrand factor multimers caused decreased ADAMTS13 protease activity. It usually presents with fever, microangiopathic hemolytic anemia, thrombocytopenia, ...

Romiplostim is a thrombopoietin receptor agonist approved for the treatment of thrombocytopenia in patients with chronic idiopathic thrombocytopenic purpura (ITP) who had an insufficient response to corticosteroids, immunoglobulins, or splenectomy. Although thrombotic and embolic complications have been reported in patients receiving romiplostim, these have generally involved coronary artery or...