Although thrombolytic therapy has been a major advance in the treatment of acute ST-segment elevation myocardial infarction (MI), new thrombolytic agents have been unable to improve early reperfusion. Because aspirin has been shown to be a very effective adjunctive agent in patients with acute MI, it has been hypothesized that the use of platelet glycoprotein (GP) IIb/IIIa receptor inhibitors c...

OBJECTIVE To examine the correlation factors for hemorrhagic transformation after intravenous thrombolytic therapy, so as to improve the forecast about hemorrhagic transformation in the process of thrombolysis, and provide theoretical basis for prognosis of the patients. PATIENTS AND METHODS A total of 1223 patients with intravenous thrombolytic therapy including NIHSS score before intravenou...

Acute myocardial infarction (AMI) evolves as a time-dependent wave front of ischemia when the abrupt rupture of an unstable fatty plaque initiates coronary thrombosis. The prospect of salvaging potentially viable myocardial tissue has led to the development of reperfusion strategies using thrombolytic agents. The efficacy of thrombolytic therapy is determined in large measure by the speed with ...

a common complication of prosthetic heart valves is thrombosis. although the incidence of prosthetic valve thrombosis (pvt) in the tricuspid position is high, there are not enough data on the management of it, in contrast to left-sided pvt. here, we describe three cases of tricuspid pvt with three different management approaches: thrombolytic therapy; close observation with oral anticoagulants;...

introduction: the precise time of using percutaneous coronary intervention (pci) after fibrinolytic therapy for maximum efficiency and minimum side effects is still undetermined. therefore, the present study was designed to compare the outcome of myocardial infarction (mi) patients who underwent surgical intervention (angiography and pci) within 48 hours of thrombolytic therapy or after that. m...

abstract sesbania grandiflora leaves are extensively used locally since ancient time as in traditional systems. base on mainly folkloric use, we investigated to know the potential of sesbania grandiflora leaves extracts through biological works in vivo and in vitro. the ethanolic extract of s. grandiflora leaves was partitioned into ethyl acetate soluble fraction (esf), petroleum ether soluble ...

Thrombolytics recanalize thrombotic occlusion associated with STsegment elevation myocardial infarction (STEMI) and restoration of coronary flow reduces infarct size and improves myocardial function and survival over the short-term and long-term. Thrombolytic therapy for acute myocardial infarction (AMI) was incorporated into the armamentarium of clinicians over 2 decades ago, and has evolved f...

There has been rapid proliferation of understanding and experience with thrombolytic therapy for acute myocardial infarction. Over the last few years, selective intracoronary infusion of lytic therapy has been replaced by intravenous administration because of the fundamental importance of time to reperfusion. Newer thrombolytic agents, such as tissue plasminogen activator (t-PA) and acylated st...

Pulmonary embolism (PE) is a common disorder that is accompanied by significant morbidity and mortality. Although anticoagulation is the standard treatment for PE, thrombolytic therapy, with its ability to produce rapid clot lysis, has long been considered an attractive alternative. Although many studies have been performed over the past three decades, however, the indications for the use of th...

or benefit from this approach. We searched for studies including two or more patients treated with throm¬ bolytic agents. Ten studies were reviewed. We de¬ scribe and include two patients with valve thrombosis treated at our institution. A total of 182 episodes of prosthetic valve thrombosis in 162 patients were ex¬ amined. Clinical success was achieved in 72.0% of cases and there was a mortali...