Context-sensing for context-aware HCI challenges the traditional sensor fusion methods with dynamic sensor configuration and measurement requirements commensurate with human perception. The Dempster-Shafer theory of evidence has uncertainty management and inference mechanisms analogous to our human reasoning process. Our Sensor Fusion for Contextaware Computing Project aims to build a generaliz...

Regulated exocytosis is thought to occur either by "full fusion," where the secretory vesicle fuses with the plasma membrane (PM) via a fusion pore that then dilates until the secretory vesicle collapses into the PM; or by "kiss-and-run," where the fusion pore does not dilate and instead rapidly reseals such that the secretory vesicle is retrieved almost fully intact. Here, we describe growing ...

Nerve terminals release neurotransmitters from vesicles into the synaptic cleft upon transient increases in intracellular Ca(2+). This exocytotic process requires the formation of trans SNARE complexes and is regulated by accessory proteins including the complexins. Here we report the crystal structure of a squid core complexin-SNARE complex at 2.95-A resolution. A helical segment of complexin ...

In this paper we investigate a new notion of bases in Hilbert spaces and similar to fusion frame theory we introduce fusion bases theory in Hilbert spaces. We also introduce a new denition of fusion dual sequence associated with a fusion basis and show that the operators of a fusion dual sequence are continuous projections. Next we dene the fusion biorthogonal sequence, Bessel fusion basis, Hil...

Ergosterol depletion independently inhibits two aspects of yeast mating: pheromone signaling and plasma membrane fusion. In signaling, ergosterol participates in the recruitment of Ste5 to a polarized site on the plasma membrane. Ergosterol is thought to form microdomains within the membrane by interacting with the long acyl chains of sphingolipids. We find that although sphingolipid-free ergos...

Fusion protein technology represents the strategy to achieve rapid, efficient, and cost-effective proteinexpression. Epsilon and Beta toxins are the most potent Clostridial toxins and cause disease in animals.This study describes in silico fusion of Clostridium perfringens types D and B epsilon and beta toxin genesthat was used for cloning in E.coli. The etx and cpb genes were...

Regulated exocytosis is thought to occur either by “full fusion,” where the secretory vesicle fuses with the plasma membrane (PM) via a fusion pore that then dilates until the secretory vesicle collapses into the PM; or by “kiss-and-run,” where the fusion pore does not dilate and instead rapidly reseals such that the secretory vesicle is retrieved almost fully intact. Here, we describe growing ...

The ATP-dependent proton pump V-ATPase ensures low intralysosomal pH, which is essential for lysosomal hydrolase activity. Based on studies with the V-ATPase inhibitor BafilomycinA1, lysosomal acidification is also thought to be required for fusion with incoming vesicles from the autophagic and endocytic pathways. Here we show that loss of V-ATPase subunits in the Drosophila fat body causes an ...

Editor’s note: This editorial launches a series written by editors and co-authored with a senior executive, thought leader, or scholar from a different field to explore new content areas and grand challenges with the goal of expanding the scope, interestingness, and relevance of the work presented in the Academy of Management Journal. The principle is to use the editorial notes as “stage setter...

Futurists agree that interposable symmetries are an interesting new topic in the field of theory, and information theorists concur. After years of extensive research into the transistor, we disconfirm the construction of IPv7, which embodies the extensive principles of evoting technology. Here we confirm not only that digital-to-analog converters and digital-toanalog converters are generally in...