This study investigated the protective effect of fish oil (FO) on cisplatin (CP) toxicity in the rat liver. Twenty-eight rats were divided equally into four groups, with the first being a control group. The second group (CP group) was given 7 mg/kg of CP and the third group (FO group) was given 1 FO softgel/rat/day for 14 days. The rats in the fourth group (CP + FO group) were treated with both...

Background: Non-alcoholic fatty liver disease (NAFLD) encompasses the entire spectrum of fatty liver disease in individuals without significant alcohol consumption and affects up to a third of the population in many developed countries. Approximately 10-30% of patients with NAFLD will progress to non-alcoholic steatohepatitis (NASH), which is associated with hepatocellular injury and inflammati...

Fatty liver is the most common type of liver disease, affecting nearly one third of the US population and more than half a billion people worldwide. Abnormalities in ER calcium handling and mitochondrial function each have been implicated in abnormal lipid droplet formation. Here we show that the type 1 isoform of the inositol 1,4,5-trisphosphate receptor (InsP3R1) specifically links ER calcium...

however, history of liver transplantation has started in 1963, but after discovery of anti-rejection drugs such as cyclosporine in 1980s, this method has experienced. from 1984 more than 3000 patients underwent surgery and just 1680 patients in 66 liver transplantation centers have operated in 1988. every patient suffers from severe liver diseases and is in terminal stage of this disease, must ...

Liver tumors were induced in male rats of the Wistar strain by feeding p-dimethylaminoazobenzene mixed into ground rat food. Surgical biopsies were taken before the animals were fed the azo dye, after 18 weeks of feeding, and when the animals were sacrificed. Tumorous liver was classified as cholangioma, trabecula hepatoma, and apparently normal areas. DNA content (by cytophotometry), mitotic a...

The liver of the embryo chick during the first two weeks of development contains an abundance of isotropic fatty globules which represent a mixture of lipoids in which phosphorized fats predominate. During the third week of incubation the fatty globules in the liver change their physical and chemical characters. They become anisotropic and exhibit the reactions and properties of esters of chole...

Abstract Primary liver cancer is the third most common cause of cancer-related deaths worldwide with hepatocellular carcinoma (HCC) comprising vast majority cases. HCC unlike solid cancers can be diagnosed based on imaging findings alone using multiphasic contrast-enhanced computed tomography (CT) or magnetic resonance (MRI) without need for histopathological confirmation in Liver Imaging Repor...

Background: Cardiac complications due to iron overload are the most common cause of death in patients with thalassemia major. The aim of this study was to compare iron chelation effects of deferoxamine, deferasirox, and combination of deferoxamine and deferiprone on cardiac and liver iron load measured by T2* MRI. Methods: In this study, 108 patients with thalassemia major aged over 10 years...

Liver cancer is the sixth most common cancer worldwide and the third leading cause of death from cancer. Liver cancer is more prevalent in countries in East Asia, Southeast Asia and the western Central Africa.1 Liver cancer rates in North America and Western Europe, less than 10 cases per hundred thousand people in Asia and Africa between 50-150 cases per hundred thousand people.2 The inc...

background: gnathostoma spinigerum causes larva migran in human which is endemic in southeast asia. information regarding larva migration is limited. in this study, we investigated the parasite migra­tion by recovery of worms from the whole body of mouse after oral infection with advanced third stage larvae (al3). the percentage of blood eosinophils was examined in parallel. methods: mice were ...