نتایج جستجو برای: thiouracil
تعداد نتایج: 560 فیلتر نتایج به سال:
Flap endonucleases (FENs) are proposed to select their target phosphate diester by unpairing the two terminal nucleotides of duplex. Interstrand disulfide crosslinks, introduced by oxidation of thiouracil and thioguanine bases, abolished the specificity of human FEN1 for hydrolysis one nucleotide into the 5'-duplex.
In the repore in which Astwood described the use of thiouracil for the treatment of human thyrotoxicosis he was fortunately able to indicate the most serious hazard which the administration of this drug entails, that of agranulocytosis. A great volume of work has confirmed both the effect of thiouracil on thyroid hyperfunction and its occasionally toxic effect on the bone marrow. Since this idi...
Some 2-thiouracils and fused 2-thiouracils were evaluated for their cytotoxicity study .The synthesized compounds were tested for their cytotoxicity effects towards (CaCo-2) cancer cell line using SRB assay. The results showed that compound 1b displayed promising cytotoxic activity and found to be more potent than standard, doxorubicin.
Transcriptional profiling is a powerful approach for understanding development and disease. Current cell type-specific RNA purification methods have limitations, including cell dissociation trauma or inability to identify all RNA species. Here, we describe "mouse thiouracil (TU) tagging," a genetic and chemical intersectional method for covalent labeling and purification of cell type-specific R...
Data published by others have shown that thiouracil (TU) is taken up selectively during melanin synthesis following trace doses of labeled TU. The concentration in newly forming mel anin has been attributed to the incorporation of TU as a "false precursor" in the biosynthetic pathway of melanin. Information made available previously has been in terms of relative values in various tissues rather...
Thiouracilis a historically relevant anti-thyroid preparation. Because of its structure you can find it in various chemical reactions differently. In this study, the reaction of Thiouracil with Chloroacetic acid and the formation of their additive products has been investigated. This reaction is aconcerted process, and it has not been determined yet by exhaustive mechanisms. From the potential ...
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