نتایج جستجو برای: thiopurine methyltransferase
تعداد نتایج: 23287 فیلتر نتایج به سال:
A meta-analysis was conducted to decide whether to reduce an initial 6-mercaptopurine (6-MP) dose in TPMT heterozygote in the case of an initial 6-MP dose of <75 mg/m2/d and to compare the tolerable 6-MP dose among different ethnic groups. The study was undertaken according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. The differences in mean values of the to...
A 6-year-old girl diagnosed with intermediate-risk acute lymphoblastic leukemia (ALL) presented severe myelotoxicity and multiple infections during phase IB induction treatment 6-mercaptopurine (6-MP). In the subsequent phases, which included 6-MP, patient continued to show bone marrow aplasia neutropenia, necessitating numerous dose adjustments interruptions. The recommended was eventually red...
Background: 6-thioguanine (6-TG) is one of the thiopurine drugs with successful use in oncology, especially for acute lymphoblastic leukemia (ALL). 6-TG is proposed to act as an epigenetic drug affecting DNA methylation. The aim of this study was to clarify the effect of 6-TG on the proliferation, viability and expression of genes coding for the enzymes DNA methyltransferase 3A and DNA methyltr...
BACKGROUND Thiopurines are used for many cancers, including acute lymphoblastic leukemia (ALL). Patients with an inherited host defect in thiopurine methyltransferase (TPMT) are at high risk for life-threatening toxicity if treated with conventional dosages, but the impact on antileukemic efficacy is less clear. MATERIALS AND METHODS We treated thiopurine-sensitive BCR-ABL+Arf-null Tpmt+/+ AL...
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