These studies, conducted on early passage synovial cell mono-layers (derived from explant cultures of tissue obtained from patients with rheumatoid arthritis), have established that gold sodium thiomalate (GST) exposure results in dose-dependent changes in cell proliferation and protein synthesis as a consequence of the cellular accumulation of gold. The amount of gold found in the cell layer i...

Uncontrolled studies have suggested that sulphasalazine may be an effective second line agent in rheumatoid arthritis. Sulphasalazine was therefore compared with placebo and intramuscular sodium aurothiomalate in 90 patients with active rheumatoid arthritis. After six months' treatment both sulphasalazine and sodium aurothiomalate had produced significant clinical and laboratory benefit, wherea...

The interactions of SCNwith aurothiomalate (AuStm) in aqueous solution were studied by 13C NMR spectroscopy. The AuStm remains polymerized in the presence of SCN-, however, SeCNbinds to AuStm forming the NCSe-Au-Stmcomplex. This complex initially disproportionates to give Au(SeCN)2and Au(Stm)2-. The Au(SeCN)2specie eventually decomposes to give metallic gold and metallic selenium (or selenium a...

Neovascularization has a role in the propagation of rheumatoid synovitis because the spread of mononuclear cell infiltration and the growth of pannus are dependent on the growth of new blood vessels. Growth of such vessels requires local endothelial cell (EC) proliferation. Inhibition of synovial EC proliferation, therefore, would have the potential to diminish rheumatoid inflammation. We have,...

The study was conducted in thirty-two healthy, normal adult albino rabbits (1.5-2.0 kg) equally divided into four groups. Each rabbit was fed 100 g of Hindustan Gold Mohr (HGM) rabbit feed daily for a month which was fully consumed. The rabbits had free access to food and water. Fasting blood samples were drawn at the end of fourth week to obtain control values of blood sugar (6). Thereafter, 1...

Named entity recognition (NER) is used in many domains beyond the newswire text that comprises current gold-standard corpora. Recent work has used Wikipedia’s link structure to automatically generate near gold-standard annotations. Until now, these resources have only been evaluated on newswire corpora or themselves. We present the first NER evaluation on a Wikipedia gold standard (WG) corpus. ...

The objective was to analyse whether the activity of the cytochrome P450 isoenzyme CYP3A4 is altered by disease activity of rheumatoid arthritis (RA). Urinary 6b-hydroxycortisol excretion, expressed as a fraction of the urinary creatinine output, was measured in 21 patients with RA treated with three different disease-modifying anti-rheumatic drugs (DMARDs) over 24 weeks. There were no correlat...

This article outlines the development of the Australian Gold Coast Integrated Care Model based on the elements identified in contemporary research literature as essential for successful integration of care between primary care, and acute hospital services. The objectives of the model are to proactively manage high risk patients with complex and chronic conditions in collaboration with General P...