نتایج جستجو برای: thioguanine

تعداد نتایج: 1272  

Journal: :JPMA. The Journal of the Pakistan Medical Association 1995
S Ahmed M Anwar S A Siddiqui M Saleem P A Ahmad S Mushtaq

Granulocytic sarcoma is an unusual variant of myeloid malignancy most commonly encountered in the course of chronic or acute myeloid leukaemia. Of 60 patients of chronic myeloid leukaemia studied over 21 months, we encountered 6 (10%) cases of granulocytic sarcoma. Four of these had granulocytic sarcoma on their first presentation. All those who were receiving hydroxyurea did not fare well but ...

Journal: :Medicinal Chemistry Research 2021

5′-Methylthioadenosine (MTA) is a natural substrate of MTA phosphorylase (MTAP) and converted to adenine via salvage pathway for AMP production in normal healthy cells. The lack MTAP expression many solid tumors hematologic malignancies compared cells has been explored potential therapeutic strategy selectively target tumor using antimetabolites such as 5-fluorouracil (5-FU) 6-thioguanine (6-TG...

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