Schiff bases of Benzene sulfonyl hydrazide (SBSZ) (1a-e) were prepared by using various benzaldehyde derivatives. SBSZ then condensed with mercapto acetic acid. The obtained resultant 2-thiazolidinone derivatives (2a-e) 5-nitro-2furfuralidine i.e. (Z)-N-(5-((5-nitrofuran-2-yl) methylene)-4-oxo-2-substitutedthiazolidin-3-yl) benzenesulfonamide (3a-e). These further phenyl urea to yield fused het...

Novel 5H-thiazolo[3,2-a]pyrimidin-5-one derivatives linked through an ethylene bridge to various phenylpiperazine groups were prepared for evaluation as 5-HT2A receptor antagonists. The target compounds 11a–p were prepared through the initial synthesis of the 2-chloroethyl intermediates 10a–d which were then reacted with the appropriate phenylpiperazines. All compounds were tested for their ant...

The synthesis and hypnotic evaluation of a new generation of thiazolo[3,2-a][1,3]diazepine analogs are described. Those compounds exhibit potent in vivo activities as ultra-short acting hypnotics. Background of the Invention Surgical procedures require the administration of several intravenous drugs to ensure hypnosis, analgesia, relaxation and control of visceral reflex responses. The use of i...

A series of thiazolo[5,4-d]thiazole-based small molecule organic optoelectronic materials is synthesized via a straightforward microwave-activated Pd-catalyzed C-H arylation protocol. The procedure allows us to obtain extended 2,5-dithienylthiazolo[5,4-d]thiazole chromophores with tailor-made energy levels and absorption patterns, depending on the introduced (het)aryl moieties and the molecular...