نتایج جستجو برای: thiazole acetates

تعداد نتایج: 2871  

Journal: :Organic & biomolecular chemistry 2016
A Hemi Cumming Sarah L Brown Xu Tao Claire Cuyamendous Jessica J Field John H Miller Joanne E Harvey Paul H Teesdale-Spittle

Pateamine A is a naturally occurring metabolite extracted from the marine sponge Mycale hentscheli. It exhibits potent cytotoxicity towards cancer cell lines and has been shown to target protein translation initiation via inhibition of the function of eukaryotic initiation factor 4A proteins. We have synthesised a simplified analogue of pateamine A, consisting of the skeletal core of the natura...

Journal: :Journal of Inorganic and Nuclear Chemistry 1969

Journal: :Chemical communications 2015
Yan He Xinying Zhang Xuesen Fan

Novel synthesis of diversely substituted 2-(furan-3-yl)acetates via palladium-catalyzed one-pot multi-component reactions of allenols, aryl iodides, alcohols, and carbon monoxide has been developed. Notably, the formation of the title compounds features a cascade process combining carbonylation of aryl iodide, alcohoxyl carbonylation of the in situ formed allyl palladium complex, and intramolec...

Journal: :research in pharmaceutical sciences 0
leila hosseinzadeh alireza aliabadi masoud kalantari abolfazl mostafavi marzieh rahmani khajouei

quinazolinones are a group of fused heterocyclic compounds which have valuable biological properties including cytotoxic, antibacterial and antifungal activities. thiazole group-containing compounds have been also reported to have a wide range of biological activities such as antitumor, anti-inflammatory, analgesic and antibacterial effects. due to valuable cytotoxic effects of both thiazole gr...

Journal: :Chemistry & biology 1999
R Sinha Roy N L Kelleher J C Milne C T Walsh

BACKGROUND The Escherichia coli peptide antibiotic microcin B17 (MccB17) contains four oxazole and four thiazole rings, and inhibits DNA gyrase. The role of individual and tandem pairs of heterocycles in bioactivity has not been determined previously. RESULTS The two tandem 4,2-bisheterocycles in MccB17 were varied by expression of MccB17 or mutants containing altered sequences at Gly39-Ser40...

Journal: :Molecules 2017
Jorge Fernández-De la Hoz Carmen Méndez José A Salas Carlos Olano

Four novel paulomycin derivatives have been isolated from S. albus J1074 grown in MFE culture medium. These compounds are structural analogs of antibiotics 273a2α and 273a2β containing a thiazole moiety, probably originated through an intramolecular Michael addition. The novel, thiazole, moiety-containing paulomycins show a lower antibiotic activity than paulomycins A and B against Gram-positiv...

Journal: :Annual review of biochemistry 2009
Christopher T Jurgenson Tadhg P Begley Steven E Ealick

Thiamin is synthesized by most prokaryotes and by eukaryotes such as yeast and plants. In all cases, the thiazole and pyrimidine moieties are synthesized in separate branches of the pathway and coupled to form thiamin phosphate. A final phosphorylation gives thiamin pyrophosphate, the active form of the cofactor. Over the past decade or so, biochemical and structural studies have elucidated mos...

Journal: :Inorganics (Basel) 2023

Throughout human history, bacteria and fungi have caused infections that are difficult to combat. For this reason, countless research groups developed novel compounds solve problem. Thiazole benzothiazole present in different structures with interesting biological effects used develop new effective antimicrobial agents. Moreover, nitrogen atoms heterocycle allow for coordination various metals,...

Journal: :Molecules 2015
Hatem E Gaffer Mohamed E Khalifa

The solid-solid reactions of thiosemicarbazide with 4-formylantipyrine, 2-acetylpyrrole and camphor were performed to afford the thiosemicarbazones 1-3 which underwent hetero-cyclization with phenacyl bromide to furnish the corresponding thiazole derivatives 4-6. The yields of the reactions are quantitative in all cases and the products do not require further purification. A series of 5-arylazo...

Journal: :Organic & biomolecular chemistry 2015
Y Le Gal D Ameline N Bellec A Vacher T Roisnel V Dorcet O Jeannin D Lorcy

Different approaches have been studied in order to prepare efficiently the sulfur rich electron acceptor, DEBTTT. Among the various routes used, the one going through the synthesis of a bicyclic derivative, where the thiazole-2-chalcogenone is fused with a 1,3-dithiole-2-one, leads to the target molecule under milder conditions and better yield. Thus, this approach has been explored for the syn...

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