hie-124 is a new member of ultra-short acting hypnotics’ drug family. in this research, the synthesis ofanalogues of hie-124 drug in the heterocyclic thiazole ring replaced to thiadiazole, will be presented.thiadiazolodiazepines during a two-step reaction starting from the amino thiadiazole resultedfrom-various derivatives of benzoic acid and thiosemicarbazide were synthesized. in the first ste...

Picene, which is an organic p-channel semiconductor and a component of superconductors, was derivatized with a thiadiazole-dioxide moiety to afford a novel acceptor molecule (PTDAO₂). PTDAO₂ can form stable anion radical species in solution and as a crystal, and its neutral crystalline thin film exhibits n-type transistor characteristics.

The 2-amino-5-(2,4-dihydroxyphenyl)-1,3,4-thiadiazole set are well known compounds with interesting in vitro and in vivo anti-cancer profiles. The aim of this study was an in vitro evaluation of the anti-cancer activity of a new synthesized aminothiadiazole derivative 2-(3-chlorophenyloamino)-5-(2,4-dihydroxyphenyl)- -1,3,4-thiadiazole 4ClABT. The effect on tumor cell proliferation, motility an...

A number of new substituted 1,2,4-triazole, 1,2,4-triazolo[3,4-b]1,3,4-thiadiazole and 1,2,4-triazolo[3,4-b]1,3,4-thiadiazine derivatives were synthesized and tested for their antimicrobial activity against Bacillus subtilis (Gram-positive), Pseudomonas aeruginosa (Gram-negative), and Streptomyces species (Actinomycetes). The synthesized compounds displayed different degrees of antimicrobial ac...

The molecular structure of a macrocycle with a 24-membered ring, a thiadiazole-containing expanded heteroazaporphyrinoid, has been, for the first time, directly characterised by a synchronous gas electron diffraction and mass spectrometric experiment and DFT calculations; the molecule has the equilibrium structure of C(3h) symmetry with a planar macrocycle.

Full color luminogens are constructed from tetraphenylethene, benzo-2,1,3-thiadiazole and thiophene building blocks. OLED fabricated using one of the luminogens exhibits orange-red electroluminescence with high luminance and efficiencies of 8330 cd m(-2), 6.1 cd A(-1) and 3.1%, respectively.

The synthetic utility of 3,3'-(3,4-dimethylthieno[2,3-b]thiophene-2,5-diyl)bis (3-oxopropanenitrile) (1) in the synthesis of some novel bis-[1,3,4-thiadiazole] 6a-g and bis-thiazole 10 and 13 derivatives with thieno[2,3-b]thiophene moiety is reported. Antimicrobial evaluation of some selected examples from the synthesized products was carried out and showed promising results.

Two new series of various heterocyclic bis-Schiff bases Thiadiazoles disulfides and thioethers are synthesized. The first was the synthesis thiadiazole (4a-h) synthesized from their corresponding Schiff after oxidation by hydrogen peroxide. second base (7a-h). It obtained reaction bis-thiadiazole diamine (6) with different aldehyde. generated reacting dibromoethane in dimethylformamide triethyl...

A library of 26 electron donor-acceptor organophotocatalysts based on the benzo[ c ][1,2,5]thiadiazole (BTZ) group has been developed. These visible light were then used in a Minisci-type alkylation heteroarenes under both batch and continuous flow conditions.