The determination of kinetic and thermodynamic data from hyperthermophilic enzymes at physiological temperature (i. e. ‡ 80 C) raises a number of technical and fundamental problems. Based on studies of purified enzymes from the model organism Pyrococcus furiosus several of these problems are identified and explored here. It is proposed that kinetic and thermodynamic data on hyperthermophilic en...

The magnetization of a system of many mesoscopic rings under nonequilibrium conditions is considered. The corresponding disorder-averaged current in a ring I(phi) is shown to be a sum of the "thermodynamic" and "kinetic" contributions both resulting from the electron-electron interaction. The thermodynamic part can be expressed through the diagonal matrix elements J(micro micro) of the current ...

Chapman-Enskog expansion is the orthodox approach to derive continuum flow models from Boltzmann’s kinetic equation for dilute gases. Beyond the Navier-Stokes-Fourier order, these models known as Burnett hydrodynamic-regime equations violate a number of fundamental mechanical and thermodynamic principles in their original forms. This has generated a widely investigated problem in the kinetic th...

In this study, reactions of the simple cycloalkynes with substituted Nitrile Oxides, by DFT method will be discussed. The investigation of the structural properties, theoretical thermodynamic and kinetic data, i.e., the activation free energies(DG*), the free energies changes of reaction(DrG) and rate constants of the reactions (k) in 298 K and effects of Electron-withdrawing and...

The critical radius of a nucleus grown by diffusion in a solution is studied thermodynamically as well as kinetically. The thermodynamic growth equation called Zeldovich equation of classical nucleation theory and the kinetic diffusional growth equation combined with the Ostwald-Freundlich boundary condition lead to the same critical radius. However, it should be pointed out that the diffusiona...

We report here kinetic and thermodynamic studies on differential isomerization of intramolecular Pyr*Pur.Pyr triplexes in supercoiled plasmids. Two structural isomers of the triplex exist: one with the 3'-half of the Pyr strand as the third strand (H-y3 form) and the other with the 5'-half as the third strand (H-y5 form). The relative populations of the two triplex isomers was determined using ...

Process simulation represents an important tool for plant design and optimization, either applied to well established or to newly developed processes. Suitable thermodynamic packages should be selected in order to properly describe the behavior of reactors and unit operations and to precisely define phase equilibria. Moreover, a detailed and representative kinetic scheme should be available to ...

Until quite recently it has been generally believed that the observed tertiary structure of a protein is controlled by thermodynamic and not kinetic processes. In this essay we review several recent results which call into question the universality of the thermodynamic hypothesis and discuss their implications for the understanding of protein folding.

We examine the ability of our recently introduced minimalist protein model to reproduce experimentally measured thermodynamic and kinetic changes upon sequence mutation in the well-studied immunoglobulin-binding protein L. We have examined five different sequence mutations of protein L that are meant to mimic the same mutation type studied experimentally: two different mutations which disrupt t...