: Metastasis spreading confers a worse prognosis to the clinical outcome among patients suffering from osteosarcoma, most common primary bone tumor in childhood and adolescence. The detection of molecules involved metastasis might contribute understanding dissemination mechanisms, thereby opening way novel therapeutic strategies. Ezrin-radixin-moesin (ERM) family proteins are activated after in...

the health and therapeutic employees are facing with some particular hazards. the existing insurance system has a lot of different shortcomings. determination of the frequency and type of accidents in a hospital was the main objective. all accidents were recorded and the study period was divided in to 3 periods. the victims who reported their accident were classified from personality point of v...

HIV-1 integrase (IN) enzyme, one of the three main enzymes of HIV-1, catalyzed the insertion of the viral DNA into the genome of host cells. Because of the lack of its homologue in human cells and its essential role in HIV-1 replication, IN inhibition represents an attractive therapeutic target for HIV-1 treatment. Since identification of IN as a promising therapeutic target, a major progress h...

HIV-1 integrase (IN) enzyme, one of the three main enzymes of HIV-1, catalyzed the insertion of the viral DNA into the genome of host cells. Because of the lack of its homologue in human cells and its essential role in HIV-1 replication, IN inhibition represents an attractive therapeutic target for HIV-1 treatment. Since identification of IN as a promising therapeutic target, a major progress h...

fuller, in 1989, described probiotic microorganisms as “a live microbial feed supplement,which beneficially affects the host animal, by improving its intestinal microbial balance”.saccharomyces cerevisiae var. boulardii (s.boulardii) is an accurate probiotic yeast idol.the detection and budding of s.boulardiiis firmly related to the impression of healthinessto promote microorganisms from foodst...

background: mesenchymal stem cells (mscs) have been recently received increasing attention for cell-based therapy, especially in regenerative medicine. however, the low survival rate of these cells restricts their therapeutic applications. it is hypothesized that autophagy might play an important role in cellular homeostasis and survival. this study aims to investigate the regenerative potentia...

Microbes release important metabolites that regulate various physiological activities inside and outside of organisms. The human gastrointestinal tract is a reservoir microbes play regulatory roles in modulating the immune system numerous other functions. Thus, there substantial interest these microbial products their clinical significance. These have shown promise as therapies for cancer, infl...

Abstract Reactive oxygen species (ROS) are not only toxic agents but also potent signaling molecules. NADPH oxidases the sole enzymes to generate ROS playing an important role in redox signaling. They closely interact several ways with hypoxia-inducible transcription factors of HIF family. This network is active under normoxic and hypoxic conditions as regulator homeostasis. Members oxidases-HI...

Fibroblast activation is a hallmark feature of pathological remodeling the heart and represents an attractive target for therapeutic intervention. Pharmacological inhibition chromatin enzymes reduces cardiac fibrosis, but underlying transcriptional regulatory mechanisms remain poorly understood. Using single-cell genomics to profile alterations in landscape during stress-induced remodeling, Ale...