Epidermolysis bullosa (EB) is a rare, serious genetic disease, incurable through the current means. Apart from this initial definition, there was later some ease in definition of including manifestations toxic epidermal necrolysis and Stevens Johnson syndrome entity. In medical practice, are cases that do not overlap with description literature, thus treatment must be adapted personalized to pa...

OBJECTIVE The availability of weekly subcutaneous infusions of subcutaneous immunoglobulin (SCIg) provides an additional therapeutic option for patients with primary immunodeficiency disease. With proper patient education, individuals can safely transition to SCIg therapy and experience minimal side effects. RESEARCH DESIGN Case reports. RESULTS A plan for successful implementation of SCIg ...

BACKGROUND AND AIM Oral bisphosphonates have been shown to reduce the risk of fractures in patients with osteoporosis. It can be assumed that the clinical effectiveness of oral bisphosphonates depends on persistence with therapy. METHODS The influence of persistence with and adherence to oral bisphosphonates on fracture risk in a real-life setting was investigated. Data from 4451 patients wit...

BACKGROUND Noncompliance with bisphosphonate therapy among osteoporosis patients attenuates the reduction of fracture risk. The objective of this study was to assess physicians' prescribing considerations, preferences for osteoporosis treatments, and perceptions of patients' compliance with oral bisphosphonates. METHODS This was an online survey of US physicians identified in the HealthCore I...

Children with medulloblastoma in Bristol are treated surgically and with craniospinal irradiation, and in some cases chemotherapy. Thirteen medium or long term survivors were investigated to determine their growth and endocrine function. Their rate of growth was considerably reduced through the first year of their illness and after spinal irradiation spinal growth was poor. Nine children develo...

Focal segmental glomerulosclerosis (FSGS) is a renal pathology finding that represents a constellation of rare kidney diseases, which manifest as proteinuria, edema nephrotic syndrome, hypertension, and increased risk for kidney failure. Therapeutic options for FSGS are reviewed displaying the expected efficacy from 25 to 69% depending on specific therapy, patient characteristics, cost, and com...

PURPOSE Days supply (prescription duration) values are commonly used to estimate drug exposure and quantify adherence to therapy, yet accuracy is not routinely assessed, and potential inaccurate reporting has been previously identified. We examined the impact of cleaning days supply values on the measurement of adherence to oral bisphosphonates. METHODS We identified new users of oral bisphos...

in the last three decades investigations in the field of oxadiazoles have been intensified due to their diverse therapeutic uses. oxadiazole are well known to have a wide range of therapeutic activities namely anti-inflammatory, analgesic, antipyretic, anticonvulsant, antiparasitic, antimicrobial etc. in this study, we have evaluated the antimicrobial activity of some carboxymethyl derivatives ...