Abstract Cancer remains a major health problem that plagues human beings, calling widespread attention to develop novel theranostics achieve sensitive diagnosis and efficient therapy. Multifunctional nanomedicine can integrate with treatment formulations has been emerging as powerful strategy overcome the current drawbacks in conventional clinical cancer treatments. Due good biocompatibility, e...

A novel hybrid nanoporous material (LNH-1) bearing a tris(propyliminomethyl)-phloroglucinol fluorescent moiety in the framework has been designed and administration of an LNH-1 based drug delivery system containing doxorubicin to cancer cells showed inhibition of proliferation, suggesting its future potential theranostics application in cancer.

This commentary highlights the findings by Tao et al. (Theranostics 2016; 6: 2068-2083) that targeting miR-433 may be a potential therapeutic strategy for myocardial fibrosis and subsequently discusses the obstacles and prospects associated with the application of therapeutic microRNAs in anti-fibrosis treatment.

Genomic variation can lead to differential drug responses in individual patients, affecting drug absorption, metabolism, pharmacodynamics and excretion. Very often, polymorphisms in genes regulating these mechanisms are responsible for individual variability. The use of genome-wide association studies (GWAS) has enhanced the ability to identify such genetic variation, highlighting specific subg...