Midazolam clearance is used to phenotype hepatic CYP3A activity but requires multiple plasma samples following a single intravenous dose. The authors evaluated the use of a limited sampling scheme, using different assay techniques to determine the reproducibility of such a strategy in estimating midazolam AUC. Seventy-three healthy adults received midazolam as a single intravenous bolus dose. A...

Previous analyses of car theft data from the British Crime Survey (BCS) have suggested that usual place of parking (e.g., in the street or in a garage) is related to risk of theft, even allowing for the fact that parking options vary with otherfactors (such as living in an inner city) that themselves affect risk. However, theft risks have been assessed for people usually parking in different lo...

Groundwater quality management is the most important issue in many arid and semi-arid countries, including Iran.Artificial neural network (ANN) has an extensive range of applications in water resources management. In this study,artificial neural network was developed using MATLAB R2013 software package, and Cl, EC, SO4 and NO3 qualitativeparameters were estimated and compared with the measured ...

Since it was firstly introduced by Torra and Narukawa (The 18th IEEE International Conference on Fuzzy Systems, Jeju Island, Korea, 2009, pp. 1378–1382), the hesitant fuzzy set has attracted more and more attention due to its powerfulness and efficiency in representing uncertainty and vagueness. This paper extends the classical VIKOR (vlsekriterijumska optimizacija i kompromisno resenje in serb...

to clarify the genetic relationships among the lidia breed lineages and two main portuguese lidia bovine populations, casta portuguesa and brava dos açores, 24 autosomal microsatellites were analyzed in 120 samples. brava dos açores showed the highest observed and expected heterozygosity (0.73 and 0.70, respectively) while casta portuguesa showed the lowest observed and expected heterozygosity ...

This study investigates the relationship between the epidemiology of hand fractures and social deprivation. Data were collected prospectively in a single trauma unit serving a well-defined population. The 1382 patients treated for 1569 fractures of the metacarpals or phalanges represented an incidence of hand fracture of 3.7 per 1000 per year for men and 1.3 per 1000 per year for women. Depriva...

Purpose: The purpose of this study is to investigatethe effect gender differences on foreign languagelearning.Methodology: adopted a desktopmethodology. Desk research refers secondary dataor that which can be collected without fieldwork.Desk basically involved in collecting datafrom existing resources hence it often considered alow cost technique as compared field research, asthe main executive...