Protein farnesylation is a form of posttranslational modification that occurs in most, if not all, eukaryotic cells. Inhibitors of protein farnesyltransferase (PFTIs) have been developed as anticancer chemotherapeutic agents. Using the knowledge gained from the development of PFTIs for the treatment of cancer, researchers are currently investigating the use of PFTIs for the treatment of eukaryo...

To the Editor: We read with great interest the study by Majid et al describing pulmonary function tests (PFTs) and flow-volume loops in patients with tracheobronchomalacia.1 A central question is whether abnormalities in the PFT results and flow-volume loops are attributable to tracheobronchomalacia or concomitant lungdisease (eg,COPDorasthma). A secondary question that remains unaddressed is w...

Protein geranylgeranyltransferase type I (PGGT-I) and protein farnesyltransferase (PFT) occur in many eukaryotic cells. Both consist of two subunits, the common alpha subunit and a distinct beta subunit. In the gene database of protozoa Trypanosoma cruzi, the causative agent of Chagas' disease, a putative protein that consists of 401 amino acids with approximately 20% amino acid sequence identi...

A Cu(2+) ensemble polyfluorene derivative, poly[5,5'-(((9H-fluorene-9,9-diyl)bis(hexane-6,1-diyl))bis(oxy))diisophthalate] sodium salt (PFT), displays unprecedented selectivity for PPi (LOD = 2.26 ppb) in aqueous solution as well as in random urine samples at physiological pH vis-a-vis monitoring ALP activity. Furthermore, intracellular imaging of Cu(2+) and PPi in mouse macrophage (J774A.1) an...

Tipifarnib (R115777), an inhibitor of human protein farnesyltransferase (PFT), is shown to be a highly potent inhibitor of Trypanosoma cruzi growth (ED(50) = 4 nM). Surprisingly, this is due to the inhibition of cytochrome P450 sterol 14-demethylase (CYP51, EC 1.14.13.70). Homology models of the T. cruzi CYP51 were used for the prediction of the binding modes of the substrate lanosterol and of ...

background: pulmonary function tests (pfts) are used in assessing physiological to clinical status of the respiratory system, which is expressed as a percentage of predicted values. predicted pfts values are varies in different ethnics. predicted pfts values were studied in a sample of iranian children. materials and methods: prediction equations for pfts were derived from urban children in the...

An environmental-cum-epidemiological study was carried out by NIOH to assess the health effects in miners exposed to manganese based on clinical observations, pulmonary function tests (PFT) and neuroendocrine functions. The results of the environmental monitoring of manganese dust in manganese mines were reported last year. During the current year the results of medical examination, PFT and neu...

 ABSTRACT Background: The current practice to measure RV is either by BPG or helium dilution methods which may not be available in all clinics due to their cost. Methods: This paper outlines a method for both direct and indirect calculation of RV via PFT with acceptable sensitivity (81 %, 60% ), specificity (71 %, 94%) and validity (76%, 78%) for obstructive and restrictive lung disease respect...