نتایج جستجو برای: tfv
تعداد نتایج: 187 فیلتر نتایج به سال:
Abstract Clinical studies have validated that antiretroviral (ARV) drugs can serve as an HIV pre-exposure prophylactic (PrEP) strategy. Dosing adherence remains a crucial factor determining the final efficacy outcomes, and both long-acting implants injectable depot systems are being developed to improve patient adherence. Here, we describe platform exploits new mechanism for formation controlle...
K65R is a primary reverse transcriptase (RT) mutation selected in human immunodeficiency virus type 1-infected patients taking antiretroviral regimens containing tenofovir disoproxil fumarate or other nucleoside analog RT drugs. We determined the crystal structures of K65R mutant RT cross-linked to double-stranded DNA and in complexes with tenofovir diphosphate (TFV-DP) or dATP. The crystals pe...
Analysis of aging and pharmacogenetics (PGx) on antiretroviral pharmacokinetics (PKs) could inform precision dosing for older human HIV-infected patients. Seventy-four participants receiving either atazanavir/ritonavir (ATV/RTV) or efavirenz (EFV) with tenofovir/emtricitabine (TFV/FTC) provided PK and PGx information. Aging-PGx-PK association and interaction analyses were conducted using one-wa...
A rapid, sensitive and highly specific detection method for Aquareovirus based on reverse-transcription polymerase chain reaction (RT-PCR) was developed. Based on multiple sequence alignment of the cloned sequences of a local isolates, the Threadfin reovirus (TFV) and Guppy reovirus (GPV) with Grass carp reovirus (GCRV), a pair of degenerate primers was selected carefully and synthesized. Using...
OBJECTIVES The purpose of Project Gel was to determine the safety and acceptability of rectal microbicides in young men who have sex with men (MSM) and transgender women (TGW) at risk of HIV infection. METHODS MSM and TGW aged 18-30 years were enrolled at three sites; Pittsburgh, PA; Boston, MA; and San Juan, PR. Stage 1A was a cross-sectional assessment of sexual health and behavior in MSM a...
OBJECTIVE This report presents tenofovir (TFV) alafenamide (TAF) and elvitegravir (EVG) fabricated into nanoparticles for subcutaneous delivery as prevention strategy. DESIGN Prospective prevention study in humanized bone marrow-liver-thymus (hu-BLT) mice. METHODS Using an oil-in-water emulsion solvent evaporation technique, TAF + EVG drugs were entrapped together into nanoparticles contain...
Abstract Background Strict adherence to antiretroviral-based microbicide use is important for effective HIV prevention. We previously developed a composite measure of product adherence, protocol compliance, and semen exposure determining vaginal tenofovir (TFV) 1% gel applicators through biomarkers residual drug analyses. In this study, we tested the ability in vaginally used TFV from Phase III...
24 We compared the preclinical safety and efficacy of Tenofovir (TFV) 1% gel and 25 MZC gel containing 50 μM MIV-150 (M), 14 mM Zn(O2CCH3)2(H2O)2 (Z) and 3% 26 carrageenan (C) through a series of in vitro, ex vivo and in vivo assays. Both gels 27 showed good antiviral therapeutic indexes (>25-800). MZC showed greater anti28 SHIV-RT activity than TFV 1% gel in rhesus macaque vaginal explants. MZ...
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