نتایج جستجو برای: tetracyclic graph
تعداد نتایج: 198616 فیلتر نتایج به سال:
Microbial-catalyzed biotransformations have considerable potential for the generation of an enormous variety of structurally diversified organic compounds, especially natural products with complex structures like triterpenoids. They offer efficient and economical ways to produce semi-synthetic analogues and novel lead molecules. Microorganisms such as bacteria and fungi could catalyze chemo-, r...
We describe herein the first access to 12-membered cyclic[7,0]ortho,meta-diarylheptanoids. The key features of synthesis include both a Suzuki-Miyaura coupling and ring closing metathesis. Actinidione, promising natural product, along with bioactive tetracyclic derivative were obtained in 14 steps for time from cheap commercially available substrates an overall yield 18-21%. Our modus operandi ...
Herein, a copper(II)-catalyzed dearomative cyclization amination of N-(2-aminobenzoyl) indoles is presented. Under mild reaction conditions, the proceeds to afford tetracyclic indolines by forming new C−N bond in good yields. The 5a,6-dihydroindolo[2,1-b]quinazolin-12(5H)-ones are obtained excellent yields (up 99% yield) using trifluoromethanesulfonic acid (TfOH) mediated N−Ts cleavage. compoun...
reaction of tryptamine 1 with dimethyl -3-methoxyallylidenemalonate 2 afforded n?-[4,4-bis (methoxycarbonyl)-1,3-butadienyl] tryptamine 3 which in combination with acetylchloride and pyridine in dichloromethane gave n?, n?-[acetyl]-[(4,4-dinethoxycarbonyl) 1,3butadienyl] tryptamine 4. treatment of 3 with sodium hydroxide afforded 2h[n-(3-indolyl) ethyl] 2-oxo-3-methoxycarbonyl-1-pyridine 5. cyc...
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