نتایج جستجو برای: tetra arms pcr
تعداد نتایج: 209595 فیلتر نتایج به سال:
Atherosclerosis is one of the most important coronary artery disease (CAD) caused by lipid accumulation, hypertension, smoking, and many other factors such as environmental and genetic factors. It has been recorded that genetic variations in rs10757278 and rs1333049 are correlated with CAD. In the present study, 100 blood samples were collected (50 CAD patients and 50 appeared to be healthy con...
We have developed a novel double Amplification Refractory Mutation System (double ARMS) using a highly polymorphic region 5' to the human delta-globin gene as a model system. The double ARMS approach involves using two allele-specific ARMS primers simultaneously during DNA amplification by the polymerase chain reaction (PCR). The resulting system is highly sensitive and more specific than singl...
Type 2 diabetes mellitus is a worldwide epidemic disorder with considerable health and economic consequences. Metformin is one of the most commonly prescribed oral antidiabetic drugs. Pharmacogenetic studies showed that variants in genes related to the pharmacokinetics of metformin were associated with glucose-lowering effect of metformin. The aim of this study was to evaluate pharmacogenetic v...
Single-nucleotide polymorphisms (SNPs) in miRNAsmay alter its expression levels or processing and contribute to susceptibility to a wide range of diseases. Our study aimed to evaluate the possible association between miRNA-146a rs2910164 and miRNA-499 rs3746444 polymorphisms and susceptibility to pulmonary tuberculosis (PTB) in a sample of Iranian population. This case- control study was perfor...
backgrounds and aims: p53 gene is regarded important in pathogenesis of different cancers. therefore, this study aimed to investigate the frequency of p53 gene codon 72 arg/pro polymorphism in women suffering from breast cancer. materials and methods: a total of 90 patients with breast cancer and 83 matched healthy control women participated in this case-control study. genomic dna was extracted...
مقدمه: تغییر ساختار پروتئین های بدن می تواند منجر به تولید آنتی بادی ضد پروتئین های خودی شود. احتمالاً ایجاد پلی مورفیسم در ژن کدکننده ی آنزیم پراکسیداز تیروئید (tpo) و تغییر ساختار آن می تواند باعث تولید آنتی بادی ضد این پروتئین (anti-tpo) شود. اختلال در آنزیمtpo می تواند یکی از دلایل اصلی بیماری کم کاری تیروئید باشد که شیوع و گسترش این بیماری ما را بر آن داشت تا در این مطالعه به بررسی ارتباط پ...
Amaç: Koroner arter hastalığı (KAH), Amerika Birleşik Devletleri ve diğer gelişmiş ülkelerde ilk ölüm nedeni olan, dünyadaki en yüksek oranına sahip hastalıklardan biridir. Bireylerin yaşam kalitesinin arttırılması açısından koroner hastalığına yatkınlığın olup olmadığının erken zamanda öğrenilebilmesi, önlem alınması veya tedavi şansının oluşturulabilmesi için genetik alt yapısının belirlenmes...
Background: JAK2 is a nonreceptor tyrosine kinase that plays a major role in myeloid disorders. This mutation is characterized by a G to T transverse at nucleotide 1849 in exon 12 of the JAK2 gene, located on the chromosome 9p, leading to a substitution of valine to phenylalanine at amino acid position 617 in the JAK2 protein. In this study we compared the amplification refractory mutation (ARM...
مقدمه: حدود نیمی از موارد ناباروری زوجین به علت عوامل مردانه است. آزواسپرمی یا الیگواسپرمی شدید و بدون علت که در نتیجه تغییرات ژنتیکی حاصل می شود، بخش مهمی از ناباروری مردان را تشکیل می دهد. یک مرحله مهم در فرآیند اسپرماتوژنزیس وقایع کراسینگ اور در حین نوترکیبی هومولوگ در تقسیم میوز است. پروتئین mlh3 نقش اساسی در فرآیند نوترکیبی و اسپرماتوژنزیس دارد. این مطالعه به بررسی رابطه یک پلی مورفیسم عمل...
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