The present study was carried out to explore the possible relation of plasma plasminogen activator inhibitor-1 (PAI-1), fibrinogen, and factor VII levels to other risk factors for coronary heart disease (CHD) and to serum sex hormone levels. The study group comprised 48 apparently healthy men. To avoid the confounding factor of obesity, correlations were determined in the 30 men in this group w...

OBJECTIVE To evaluate the relationship among urolithiasis, metabolic syndrome (MetS) and serum testosterone (T) level in men. MATERIAL AND METHODS 513 men older than 18 years were enrolled in this study: 313 of the subjects had a history of stones (group 1) and 200 had no history of stones (controls, group 2). Early morning T levels were recorded and anthropometric measurements were investiga...

The present study was carried out to explore the possible relation of plasma plasminogen activator inhibitor-1 (PAI-1), fibrinogen, and factor VII levels to other risk factors for coronary heart disease (CHD) and to serum sex hormone levels. The study group comprised 48 apparently healthy men. To avoid the confounding factor of obesity, correlations were determined in the 30 men in this group w...

This study examined the effects of testosterone (T) on the contractile properties of two sexually dimorphic forelimb muscles and one non-dimorphic muscle in male bullfrogs (Rana catesbeiana, Shaw 1802). The dimorphic muscles in castrated males with testosterone replacement (T+) achieved higher forces and lower fatigability than did castrated males without replaced testosterone (T0 males), but t...

The reproductive system is extremely susceptible to insults from exposure to exogenous steroids during development. Excess prenatal testosterone exposure programs neuroendocrine, ovarian, and metabolic deficits in the female, features seen in women with polycystic ovary disease. The objective of this study was to determine whether prenatal testosterone excess also disrupts the male reproductive...

Monogamous male birds typically allocate less e¡ort to courtship and more to parental behaviour than males of polygynous species. The seasonal pattern of testosterone (T) secretion varies accordingly. Monogamous males exhibit a spring peak in plasmaT followed by lower levels during the parental phase, while males of polygynous species continue to court females and maintain T at higher levels. T...

The hormonal treatment of sexual offenders is part of a pharmacological approach to the reduction of the sexual drive. Sexual drive reduction can also be brought about by stereotaxic neurosurgery and castration. These other methods of sexual drive reduction are closely related to the pharmacological approach, and all are dependent on the complex interactions between higher central nervous syste...

During early fetal life of males, conversion of testosterone (T) to 5a-dihydrotestosterone (DHT) via the action of 5a-reductase in the external genital tissues is essential for complete sexual differentiation of male external genitalia. Measurement of low concentrations of DHT in serum of affected prepubertal males confirms the type of sexual disorder (1,2). Although commercial methodologies ha...

Lovering, Richard M., and William A. Romani. Effect of testosterone on the female anterior cruciate ligament. Am J Physiol Regul Integr Comp Physiol 289: R15–R22, 2005. First published March 24, 2005; doi:10.1152/ajpregu.00829.2004.—Injuries to the anterior cruciate ligament (ACL) result in immediate and long-term morbidity and expense. Young women are more likely to sustain ACL injuries than m...

The present study examined the effects of the androgen steroid, dihydrotestosterone (DHT), on murine T-cell production of a number of lymphokines. Direct exposure of murine T cells to DHT in vitro was found to reduce the amount of interleukin-4 (IL-4), IL-5, and gamma-interferon (gamma IFN) produced after activation with anti-CD3 without affecting the production of IL-2. Exposure of T cells to ...