Background: Acyclovir (9-(2-hydroxyethoxymethyl) guanine) (ACV) is an acyclic nucleoside analogue that has shown a potent antiviral activity, and it is known to inhibit the replication of herpesviruses including herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2), varicella- zoster virus (VZV), and Epstein-Barr virus (EBV) in cell cultures and in animals. ACV is khown to be toxic to gonads,t...

A testis biopsy is used to assess quantitatively testicular spermatogenesis in infertile patients. Recently, several reports have used less invasive, percutaneous methods to obtain testis tissue. Percutaneous testis biopsies and touch imprints, immediately followed by open testis biopsies, were performed on 24 testes (19 patients) to ascertain whether they could provide the same histological in...

Background: Experimentally induced diabetes in male rats is associated with alteration in functions of reproductive system. Acarbose, Pioglitazone and Repaglinide via decrease in blood glucose level can prevent the damage of testes. Materials and Methods: A total of 96 adult male albino rats whit a body weighing between 230- 250 g were injected by a single intraperitoneal injection of streptozo...

Background: Vasectomy is a simple and highly effective contraceptive method with a low morbidity rate and an extremely low mortality rate. during the past decade millions of men have undergone vasectomy, but there have been surprisingly few studies of morphological effects of genital organs after vasectomy. The most important issues about vasectomy are degenerative changes in testicular tissue,...

The assessment of the indicators reproductive potential male white rats exposed to smoke for 1 month was carried out. Examination animals included determination spermatogenesis index and level DNA fragmentation methylation in testes blood. A statistically signifi-cant increase genome-wide blood revealed. morphometric study testis tissue revealed a violation indices rats.

Abstract Testicular development and function rely on interactions between somatic cells the germline, but similar to other organs, regenerative capacity declines in aging disease. Whether adult testis maintains a reserve progenitor population remains uncertain. Here, we characterize recently identified mouse interstitial expressing transcription factor Tcf21. We found that TCF21 lin are bipoten...

background: spermatogonial stem cells are subpopulation of spermatogonial cells in testis tissue that support beginning and maintenance of spermatogenesis. ubiquitin carboxy-terminal hydrolase l1 (uchl1) could be a specific marker for identification of spermatogonial stem cells including spermatogonial sperm cells (sscs) in testis tissue and during the culture; therefore we undertook this study...

Xenografting of testis tissue from immature males from several mammalian species to immunodeficient mouse hosts results in production of fertilization-competent sperm. However, the efficiency of testis tissue xenografting from adult donors has not been critically evaluated. Testis tissue xenografting from sexually mature animals could provide an option to preserve the genetic material from valu...

Fluoxetine is a selective serotonin reuptake inhibitor is commonly prescribed to treat maternal depression in pregnancy and lactation. This study aimed to investigate the effects of maternal exposure to fluoxetine via lactation on testicular tissue, sperm parameters including count, motility, viability, and normal morphology and testicular oxidative stress status in male mice offspring. Ten mic...