Chloroquine is frequently used to treat systemic autoimmune diseases, such as systemic lupus erythematosus (SLE). With long term treatment, associated toxicity is well known, with retinopathy been the most common complication. Other chronic complications include skin disorders (hyperpigmentation), blood dyscrasias, corneal deposits, encephalopathy, neuropathy, myopathy, and impairment of audito...

We tested two hypotheses: 1) that fibrin-containing fibrinoid-filled denudations of the syncytiotrophoblast may provide a route for paracellular diffusion and 2) that placentas from women who had elevated maternal serum alphafetoprotein (MSAFP) in midgestation had raised permeability to AFP and greater denudation than in normal pregnancy. We measured AFP and creatinine clearance across term pla...

Transgressive deposits accumulate with rising relative sea level during the landward migration of a coastline. Particularly at short time scales (e.g., 4thto 6th-order cycles), transgressive deposits can be recognised through the evidence of a gradual or irregular landward shift of facies, or an upward deepening of facies that culminates in a surface or zone of maximum flooding. During transgre...

The international financial system has grown and evolved immensely over the past two decades. In the late 1950's the Eurocurrency market was only beginning to emerge, for all practical purposes there was no Eurobond market, and extensions of commercial credits were limited to the old commercial banking function of short term trade financing. All of that has changed. Total deposits in the Eurodo...

Aging of glass RPCs has been extensively studied along the last years. Most authors refer effects such as an increase of dark counting rate, reduction of the counter efficiency and the appearance of deposits over the electrodes surfaces. Understanding the origin of these deposits and their effect on the counter performance is of considerable practical importance. In this study, aimed at timing ...

A long-term goal of our sediment transport and accumulation investigations is to link sedimenttransport processes to the formation and preservation of event beds in sediment deposits. The general aim of this project is to investigate how forcing processes affect the sediment-transport dynamics that act to import or export fine-grained sediment in intertidal regions. We strive to understand how ...

The size frequency distributions of beta-amyloid (A beta) and prion protein (PrPsc) deposits were studied in Alzheimer's disease (AD) and the variant form of Creutzfeldt-Jakob disease (vCJD) respectively. All size distributions were unimodal and positively skewed. A beta deposits reached a greater maximum size and their distributions were significantly less skewed than the PrPsc deposits. All d...

Chloroquine is frequently used to treat systemic autoimmune diseases, such as systemic lupus erythematosus (SLE). With long term treatment, associated toxicity is well known, with retinopathy been the most common complication. Other chronic complications include skin disorders (hyperpigmentation), blood dyscrasias, corneal deposits, encephalopathy, neuropathy, myopathy, and impairment of audito...