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We conducted a comprehensive analysis of clinical pharmacology evaluations in initial submissions of 56 oncology new molecular entities approved by the US Food and Drug Administration between January 2011 and April 2017. Results from studies evaluating food effect, QTc prolongation, drug-drug interactions, renal and hepatic impairment effects, and dose optimization, as well as postmarketing req...

The use of oral chemotherapy is expected to more than double in the next several years. With the increase in use of oral chemotherapy and in patient responsibility, the role of the oncology nurse must change to ensure proper management. Nurses must teach patients how to correctly and safely take oral chemotherapy, help manage side effects, and research and monitor complications such as medicati...

Multiple latent failures align to harm a patient seriously.

In this issue of Chemistry & Biology, Cokol and colleagues report a systematic study of drug interactions between antifungal compounds. Suppressive drug interactions occur more frequently than previously realized and come in different flavors with interesting implications.