BACKGROUND This multicenter, observational study was conducted in three European countries (Germany, Switzerland, and the United Kingdom) to determine the exposure of adult cigarette smokers and nonsmokers to selected cigarette smoke constituents: 1,3-butadiene, 2-naphthylamine, 4-aminobiphenyl, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), acrolein, benzene, carbon monoxide, nicotine, ...

The development of effective immunotherapeutic strategies for central nervous system (CNS) tumors requires a firm understanding of factors regulating the trafficking of tumor antigen-specific CTLs into CNS tumor lesions. Using C57BL/6 mice bearing intracranial (i.c.) ovalbumin-transfected melanoma (M05), we evaluated the efficacy and tumor homing of i.v. transferred type 1 or 2 CTLs (Tc1 or Tc2...

BACKGROUND Impaired homocysteine metabolism is associated with a number of vasculopathies including extracranial aneurysms. We analyzed the possible association of nine genetic variants of homocysteine metabolism with the occurrence of intracranial aneurysms. METHODS Caucasian patients (n = 255) treated at two German hospitals for intracranial aneurysms and local controls (n = 348) were genot...

BACKGROUND Peripheral blood CD8+ T cells expressing interferon gamma and interleukin-4 (IL-4), and lacking CD28 molecules, were responsible for the dynamic interplay between peripheral blood and inflammatory sites. INTRODUCTION The aim of the current study was to define in Behçet's disease (BD), CD8+ T-cell subsets using CD28 and CD11b monoclonal antibodies, and the characterization of the Tc...

Cross-talk between TGFand IL-6 has been shown to direct the differentiation of CD4 cells into special IL-17-secreting cells, which are termed Th17 cells. In this study, we demonstrated that TGFand IL-6 could stimulate CD8 cells to differentiate into noncytotoxic, IL-17-producing cells in MLC. These IL17-producing CD8 cells exhibit a unique granzyme BIFNIL-10 phenotype. The mRNA level of Th2/T c...

We have previously reported that oral administration of allogeneic rat spleen cells before kidney allotransplantation significantly prolongs graft survival. This prolongation was alloantigen specific and was associated with a decrease in graft-infiltrating cells (GIC) and an increase in transcription of IL-4 mRNA in the GIC. In this study increased splenic mixed lymphocyte responses from animal...

Abstract In the topcolor-assistant technicolor (TC2) model, the typical physical particles, top-pions and top-Higgs, are predicted and the existence of these particles could be regarded as the robust evidence of the model. These particles are accessible at the Tevatron and LHC, and furthermore the flavor-changing(FC) feature of the TC2 model can provide us a unique chance to probe them. In this...

BACKGROUND T lymphocytes and especially the subpopulations of CD8+ cells are believed to have a key role in COPD pathophysiology, but there are only few data regarding the role of these cells in COPD exacerbation. AIM We aimed to study prospectively changes of CD8+ T-lymphocyte subpopulations in the sputum of COPD patients at the onset of mild exacerbations and at a stable condition in order ...

This research work is mainly focused on the performance of wind turbine power plant. The plant will depends working gearbox. Hence parameters taken like inlet velocity air, temperatures and pressure air entering into For experimentation a three stage gearbox has been considered data recorded for period 5 months. These results with help SCADA software are imported from analyzing minimum maximum ...