نتایج جستجو برای: tbm downtimes
تعداد نتایج: 1531 فیلتر نتایج به سال:
Tuberculous meningitis (TBM) remains a major cause of death and disability in tuberculosis-endemic areas, especially in young children and immunocompromised adults. Research aimed at improving outcomes is hampered by poor standardization, which limits study comparison and the generalizability of results. We propose standardized methods for the conduct of TBM clinical research that were drafted ...
This paper presents an innovative competitive approach for high-tech industries, named Technology Based Marketing (TBM). This approach is compared with other eight business approaches. Nowadays, competition is changing and becoming more dynamic and therefore more difficult. Hence, technology can be leveraged to a source of competitiveness. With the TBM approach, three types of technology can be...
Tensor based morphology (TBM) is a powerful approach to analyze local structural changes in brain anatomy. However, conventional scalar TBM methods are unable to present direction-specific analysis of volume changes required to model complex changes such as those during brain growth. In this paper, we describe novel TBM descriptors for studying direction-specific changes in a subject population...
The local production of tumour necrosis factor-alpha (TNFalpha) was evaluated in the cerebrospinal fluid (CSF) from ten patients with tuberculous meningitis (TBM). The degree of intrathecal immune activation was also studied by assessing the CSF levels of beta(2)-microglobulin (beta(2)-M) and adenosine deaminase activity (ADA). Results indicate that elevated CSF concentrations of TNFalpha, beta...
Tuberculosis is a common infectious disease caused by Mycobacterium tuberculosis. One third of world's population is infected with tuberculosis, but only 10% of them will develop the clinical disease (1). Tuberculous Meningitis (TBM) was first described as a distinct pathological entity in 1836 (2). At present, TBM is the fifth most common extrapulmonary tuberculosis in the United States (US) a...
OBJECTIVES Tuberculous meningitis (TBM) is a major clinical and public health problem, both for diagnosis and management. We compare two established scoring systems, Thwaites and the Lancet consensus scoring system for the diagnosis of TB and compare the clinical outcome in a tertiary care setting. METHODS We analyzed 306 patients with central nervous system (CNS) infection over a 5-year peri...
PURPOSE High mobility group box-1 (HMGB1) is a proinflammatory, DAMP protein that participates in many pathological conditions. In this study, we evaluated the usability of CSF HMGB1 as a biomarker for the diagnosis of tuberculous meningitis (TBM). METHODS A total of 59 TBM patients and 169 control patients were included in our study. CSF samples were obtained and analyzed for HMGB1 using a c...
The clinical and mycobacterial features of tuberculous meningitis (TBM) cases in China are not well described; especially in western provinces with poor tuberculosis control. We prospectively enrolled patients in whom TBM was considered in Shaanxi Province, northwestern China, over a 2-year period (September 2010 to December 2012). Cerebrospinal fluid specimens were cultured for Mycobacterium t...
In France, Bacillus Calmette–Guérin (BCG) vaccination by multipuncture device was withdrawn in 2006. In 2007, universal mandatory BCG vaccination was replaced by vaccination of high-risk children. To evaluate the impact of these changes on tuberculous meningitis (TBM) epidemiology, data on culture-positive and culture-negative (or unknown microbiological result) TBM in ≤5 years olds were collec...
Information concerning the size and shape of tunnel boring machine (TBM) debris is essential for designing efficient loading, hauling and dumping systems for TBM excavation. It is also very important in deciding how to recycle the TBM debris. However, only very limited information is available at present, and theoretical or calculation methods to estimate the size and shape are still open to di...
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