Pain is an important dimension of quality-of-life in patients with metastatic castrate-sensitive prostate cancer (mCSPC). However, it unclear if dynamic change pain over time can predict for overall survival (OS) or to radiographic progression (TTRP) these patients. This exploratory analysis LATITUDE, which men de novo mCSPC were randomized receive either ADT plus abiraterone versus alone. Info...

There are no detailed accounts of the connexions and branching of the axons of neurons in the pedal ganglia of opisthobranchs. Most of the experiments on these ganglia have been limited to cutting and stimulating nerve trunks, and using these techniques, Frohlich (1910) demonstrated the role of the pedal ganglia in inhibiting the tonic contraction of the isolated foot of Aplysia limacina. Ten C...

PURPOSE To examine the influence of exercise intensity on postprandial health outcomes in adolescents when exercise is accumulated throughout the day. METHODS 19 adolescents (9 male, 13.7±0.4 years old) completed three 1-day trials in a randomised order: (1) rest (CON); or four bouts of (2) 2×1 min cycling at 90% peak power with 75 s recovery (high-intensity interval exercise; HIIE); or (3) c...

OBJECTIVE Changes in insulin sensitivity (IS) and insulin secretion occur with perturbations in energy balance and glycemic load (GL) of the diet that may precede the development of insulin resistance and hyperinsulinemia. Determinants of changes in IS and insulin secretion with weight cycling in non-obese healthy subjects remain unclear. METHODS In a 6wk controlled 2-stage randomized dietary...

The excitatory post-synaptic potentials (EPSPs) of molluscan neurones presumably result, as in other cells (Fatt & Katz, 1951; Eccles, 1964), from an increase in membrane conductance to one or more ions which tends to drive the membrane toward a reversal potential near zero. Consequently, membrane hyperpolarization should increase the amplitude of an EPSP, whereas depolarization should have the...

Much of the recent work on the giant cells in the central nervous system of gastropods is related to the activity and the electrical properties of individual cells (Tauc, 1955, 1957, i960, 1962; Arvanitaki & Chalazonitis, 1956; Kerkut & Walker, 1961). Although this has greatly advanced our understanding of the physiology and pharmacology of the individual neurons, there is still much to be lear...

We discuss the implications of the recent upward revision of the LMC microlensing rate by the MACHO Collaboration. We conclude: (i) A good case for the existence of baryonic dark matter in the halo has been made; (ii) The case for the existence of cold dark matter is unaffected and still compelling; and (iii) The Galactic halo is still an excellent place to search for cold dark matter particles...

The dilator function of the vascular endothelium is critical for optimal tissue perfusion, and this is brought into stark reality in a number of diseases, such as hypertension, diabetes, and preeclampsia, in which endothelium-dependent vasodilator function is impaired. Prostacyclin and nitric oxide (NO) were the earliest identified endothelium-dependent vasodilators, but it was soon found that ...

An anticipatory system for guiding plot development in interactive narratives is described. The executable model is a finite automaton that provides the implemented system with a lookahead. The identification of undesirable future states in the model is used to guide the player, in a transparent manner. In this way, too radical twists of the plot that lead to behaviors of the autonomous fellow ...