Ionizing radiation in differentiated thyroid cancer (DTC) patients treated with radioiodine (131-I) produces reactive oxygen species (ROS), which could induce oxidative stress with disturbance of redox balance. The aim of this study was to evaluate oxidative stress in DTC patients treated with 3.7 or 5.5 GBq of 131-I using values for serum malondialdehyde (MDA, a marker of oxidative stress), ur...

PURPOSE The efficacy of targeted agents (TAs) in the treatment of elderly patients with advanced non-small-cell lung cancer (NSCLC) remains controversial. We aimed to assess the efficacy of TAs in the treatment of advanced NSCLC in this setting. MATERIALS AND METHODS Relevant trials were identified by searching electronic databases and conference meetings. Prospective randomized controlled tr...

Thymidine kinase-1 (TK-1) and thymidylate synthase (TS) are key enzymes for salvage and de novo pyrimidine synthesis, respectively. Numerous studies have suggested that increased TS levels are associated closely with resistance to fluoropyrimidine-based chemotherapy. TAS-102 is a novel drug containing trifluorothymidine, which is phosphorylated by TK-1 to its active monophosphated form, that in...

Here we use low-temperature scanning tunneling microscopy and spectroscopy to reveal the roles of narrow electronic band in two 1$T$-TaS$_2$ related materials (bulk 4$H_{\rm b}$-TaS$_2$). b}$-TaS$_2$ is a superconducting compound with alternating 1$H$-TaS$_2$ layers, where layer has weak charge density wave (CDW) pattern reduces CDW coupling between adjacent layers. In b}$-TaS$_2$, observe loca...

Two studies examined correlates of alexithymia in posttraumatic stress disorder (PTSD). In study 1 (n = 77 individuals with PTSD and 45 controls) Toronto alexithymia scale (TAS-20) scores were positively correlated with PTSD symptoms, dissociation, and childhood abuse and neglect. In study 2, TAS-20 scores were examined as correlates of functional magnetic resonance imaging (fMRI) blood oxygen ...

We report new developments in the TAS: the Test of Adult Speechreading, a test designed to be appropriate to the needs of both deaf and hearing users [1]. Profoundly prelingually deaf people outperform hearing users on this test. Subtests of TAS showed different patterns of inter-correlation in deaf and hearing people, suggesting different underlying factors accounting for individual variabilit...

Graduate teaching assistants (TAs) receive little to no formal training in pedagogy before entering the classroom. Such deficiencies may contribute to increase anxiety and poor self-efficacy for TAs, potentially hindering opportunities to train future faculty. We tested the effects of a previously established, low investment, method of TA training through making and receiving peer-evaluations o...

Time Petri Nets (TPN) and Timed Automata (TA) are widely-used formalisms for the modeling and analysis of timed systems. A recently-developed approach for the analysis of TPNs concerns their translation to TAs, at which point efficient analysis tools for TAs can then be applied. One feature of much of this previous work has been the use of timed reachability analysis on the TPN in order to cons...

Recently, the synthesis of a molecule has been reported that belongs to a Lysine based, branched cyclic peptide class. This work explores the ability of such molecules to preserve the 3D geometry of the Trypsin's Active Site (TAS) by applying an integrated framework of automated computer procedures. The following four factors a) D/L chirality, b) different amino acids at different positions of ...