نتایج جستجو برای: tap2
تعداد نتایج: 687 فیلتر نتایج به سال:
Compared with the MHC of typical mammals, the chicken MHC (BF/BL region) of the B12 haplotype is smaller, simpler, and rearranged, with two classical class I genes of which only one is highly expressed. In this study, we describe the development of long-distance PCR to amplify some or all of each class I gene separately, allowing us to make the following points. First, six other haplotypes have...
Source and Description of Probe. A 2.7-kb human cDNA clone for TAP2 was excised from the XbaI site of the plasmid pRSV.5neo (Bahram et al., 1991). Method of Detection. DNA was isolated from whole blood and digested with TuqI. Fragments were separated by agarose gel electrophoresis and transferred to charged nylon membranes. Hybridizations were for 16 to 20 h at 65°C (10% dextran sulfate, 7% SDS...
PURPOSE Defects in the antigen processing machinery (APM) may provide tumor cells with a mechanism to escape immune recognition. The purpose of this study is to determine the clinical significance of APM component down-regulation and tumor-infiltrating T cells in ovarian carcinoma. EXPERIMENTAL DESIGN After institutional review board approval, tumor samples from 150 patients with invasive epi...
PURPOSE The Janus-activated kinase/signal transducers and activators of transcription (STAT) pathway of IFN signaling is important to immunoregulation and tumor progression. STAT1 plays a prominent role in the effector immune response, whereas STAT3 is implicated in tumor progression and down-regulation of the response to type I IFNs. The goal of this study was to understand the effects of high...
(MHC) class I molecules are polymorphic cell surface glycoproteins that play an essential role in immune surveillance. In the MHC class I antigen presentation pathway, peptides derived from cytosolic proteasome-mediated proteolysis are transported into the endoplasmic reticulum (ER) via the transporter associated with antigen processing (TAP), reviewed in ref. 1. In the ER lumen, translocated p...
PURPOSE The transporter associated with antigen processing (TAP) is essential in assembling MHC-I proteins. Human papillomavirus (HPV) evades immune recognition by decreasing class I MHC cell surface expression through down-regulation of TAP1 levels. Consistent with heterogeneity in MHC expression is the individual variability in clearing detectable HPV infections. Genetic polymorphisms in TAP ...
The authors consider the multilinear Riesz potential operator defined by Iα,m − → f x ∫ Rd m f1 y1 f2 y2 · · · fm ym /| x−y1, . . . , x−ym |mn−α dμ y1 · · ·dμ ym , where − → f denotes themtuple f1, f2, . . . , fm , m,n the nonnegative integers with n ≥ 2, m ≥ 1, 0 < α < mn, and μ is a nonnegative n-dimensional Borel measure. In this paper, the boundedness for the operator Iα,m on the product of...
Let’s investigate the finer points. First, let us begin by assuming that we have an n×n grid of unit squares (see Fig. 1(a)), for a relatively small number n (e.g., n might range from 2 to 10). For each vertex [i, j] of this grid, where 0 ≤ i, j ≤ n, let us generate a random scalar value z[i,j]. (Note that these values are actually not very important. In Perlin’s implementation of the noise fun...
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