BACKGROUND Four formulations of Tamoxifen citrate loaded polylactide-co-glycolide (PLGA) based nanoparticles (TNPs) were developed and characterized. Their internalization by Michigan Cancer Foundation-7 (MCF-7) breast cancer cells was also investigated. METHODS Nanoparticles were prepared by a multiple emulsion solvent evaporation method. Then the following studies were carried out: drug-exc...

conclusions we suggest avoiding the use of tamoxifen for eps in patients with superimposed calciphylaxis. introduction encapsulating peritoneal sclerosis (eps) is a rare but devastating complication of peritoneal dialysis (pd). tamoxifen has been generally well-tolerated, even without randomized controlled trials. case presentation herein, we report a case of a patient undergoing 12 years of pd...

BACKGROUND The objective of this prospective randomized study was to make a comparison between the effects of letrozole and tamoxifen (TMX) in ovulation induction in clomiphene (CC)-resistant women with polycystic ovarian syndrome (PCOS). METHODS The study comprised a total of 60 infertile women (180 cycles) with CCresistant PCOS selected from the clinics affiliated to the Department of Obste...

objective(s) the effect of tamoxifen as a selective estrogen receptor modulator which is widely used for treatment of early and metastatic breast cancer was investigated on the folliculogenesis in rat's fetuses and neonates. materials and methods the pregnant rats assigned into test and control groups. control group received olive oil and treatment groups received either 17-β-estradiol (10...

Introduction: Tamoxifen is a nonstroidal antiestrogen prescribed for treatment of breast cancer. The aim of this study was to investigate the effect of tamoxifen on testosterone level in the serum and sperm count in the epididymis of adult male Wistar rats. Methods: Three groups of rats received 200, 400 and 600 µg/kg body weight tamoxifen dissolved in solvent (60% ethanol in physiological ...

Tamoxifen is the drug of choice as hormonal therapy for hormone receptor-positive breast cancers and can reduce risk cancer recurrence. However, oral tamoxifen has a low bioavailability due to liver intestinal metabolic passes. To overcome this problem utilize potential its maximum, inorganic nanoparticle carriers have been exploited tested increase bioavailability. Biocompatibility unique magn...

Objective Tamoxifen is an effective anti-tumor medicine, but evidence has been provided on tamoxifen-related inflammation as well its impact gut microbiota. In this study, we aimed to investigate tamoxifen-induced microbiota and alteration. Methods We established a BC xenograft mouse model using the MCF-7 cell line. 16S rRNA gene sequencing was used qRT–PCR, western blotting, cytometric bead ar...

Background: The objective of this study is to evaluate combined effect of Thymoquinone (The main active component of black seeds) with Tamoxifen drug on apoptosis of human breast cancer MCF-7 cells (Noninvasive human breast cancer cell line, estrogen receptor positive). Materials and Methods: The human breast cancer MCF- 7 cells were treated with Tamoxifen (2 μM) alone or in combination with Th...

BACKGROUND Over the past few years, data have been published concerning the relative efficacy and safety profiles of tamoxifen and the aromatase inhibitors (AIs) in the adjuvant therapy setting for women with early hormone receptor-positive breast cancer. Recently, debate has centred around trials which have studied primary tamoxifen and AI therapy, switching and sequencing strategies and exten...