Benzimidazole anti-microtubule drugs, such as benomyl, induce paralysis and slow the growth of the nematode Caenorhabditis elegans. We have identified 28 mutations in C. elegans that confer resistance to benzimidazoles. All resistant mutations map to a single locus, ben-1. Virtually all these mutations are genetically dominant. Molecular cloning and DNA sequence analysis established that ben-1 ...

background: betaine has been shown to be antioxidantand methyl donor effects in our recent studies. objectives: inthe present study, the antioxidant and methyl donor properties ofbetaine in levodopa/benserazide-mediated hyperhomocysteinemiaand levodopa-induced oxidative stress in rat's kidney wereexamined. methods: sprague-dawley male rats were dividedinto levodopa (ld), betaine (bet.), levodop...

The signaling mechanisms that allow the conversion of a growth cone into a mature and stable synapse are yet to be completely understood. Ubiquitination plays key regulatory roles in synaptic development and may be involved in this process. Previous studies identified the Drosophila ubiquitin conjugase bendless (ben) to be important for central synapse formation, but the precise role it plays h...

The role of aristolochic acid in the etiology of Balkan endemic nephropathy (BEN) and associated upper urothelial carcinoma (UUC) was recently confirmed. The aim of this study was to determine the marker(s) specific for BEN-associated UUC. A total of 82 patients with UUC (38 from the BEN region and 44 control tumors) were included in the study. The Ki-67 index in BEN tumors correlated with the ...

Despite broad investigations into the possible role of genetic factors, environmental agents and immune mechanisms, the etiology of Balkan endemic nephropathy (BEN) is only partially understood. An increased incidence of upper urothelial cancer in patients with BEN and in populations from endemic settlements has been demonstrated. Genetic studies have landed support for genetic predisposition t...

BICEP2 observations, interpreted most simply, suggest an era of inflation with energy densities of order (1016GeV)4, not far below the Planck density. However, models of TeV gravity with large extra dimensions might allow a very different interpretation involving much more modest energy scales. We discuss the viability of inflation in such models, and conclude that existing scenarios do not pro...

Numune kumaş dokuma tezgâhları, işletmelerinde üretilmek istenen kumaşın seri üretime geçilmeden önce numunesini dokumak için kullanılmaktadır. Aynı zamanda tekstil alanında eğitim-öğretim faaliyeti yürüten meslek liseleri, yüksekokulları ve mühendislik fakültelerinde öğrencilerin yapıbilgisi, tasarımını öğretmek amacıyla yaygın olarak Bu çalışmada, armürlü numune makineleri tahar armür planı i...

Phosphorus Release Characteristics from Biosolids-Derived Organomineral Fertilizers Diogenes L. Antille, Ruben Sakrabani & Richard J. Godwin a School of Applied Science, Cranfield University, Cranfield, Bedfordshire, UK b National Centre for Engineering in Agriculture, University of Southern QueenslandToowoomba, Queensland, Australia c Harper Adams University, Newport, Shropshire, UK Accepted a...