Many different types of controlled dosage forms have been developed to improve clinical efficiency of drug and patient compliance. In vivo performance of these dosage forms, however, depends greatly on their physical and structural properties, and consequently on their drug release mechanisms and its kinetics. A solid complex (matrix) mostly produced by tableting techniques are commonly used in...

A near infrared (NIR) method able to directly quantify the active content in pharmaceutical powder blends used for manufacturing meloxicam tablets, without any sample preparation, was developed and fully validated. To develop calibration models for the assay of meloxicam in powder blends for tableting, the NIR reflectance spectra of different meloxicam powder blends prepared according to a cali...

Purpose: Low crystallinity celluloses (LCC) are materials that have a substantially reduced degree of crystallinity, typically ranging between 15 and 45%. It is useful as an excipient in preparation of tablets and confectionery products. The aim of this work was to obtain from αcellulose content of corn cob, a low crystallinity cellulose (LCC-CC), and study its physical properties as well as ev...

Characterization and Evaluation of the Release Kinetics a Model Poorly Water-Soluble Low Dose Drug from Matrix Tablets Composed Blends Swellable Erodible Polymers: Implications for Controlled Complete ReleaseAiman A. Obaidat

Measurement methods for determining the density of compressed materials, being a critical quality attribute, provide an important parameter successful processing. In this study, novel approach was developed compacts using ultraviolet–visible spectrophotometry. The assumption within context that change in affects corresponding color information compact. From obtained spectra visible range, compa...