Background: Magnetic resonance imaging (MRI) plays an essential role in molecular imaging by delivering the contrast agent into targeted cancer cells. The aim of this study was to evaluate the C595 monoclonal antibody-conjugated superparamagnetic iron oxide nanoparticles (SPIONs-C595) for the detection of breast cancer cell (MCF-7). Methods: The conjugation of monoclonal antibody and nanopartic...

BACKGROUND AND PURPOSE Development of callosal fibers is important for psychomotor and cognitive functions. We hypothesized that brain maturation changes are detectable beyond 2 years of age by using diffusion tensor imaging (DTI) of the corpus callosum (CC). MATERIALS AND METHODS T2 and fractional anisotropy (FA) maps of the brain of 55 healthy subjects between 0.2 and 39 years of age were o...

Introduction The rate of lipolysis of dietary fat depends critically on emulsion particle size, which influences fat absorption and metabolism. In order to study the factors affecting fat emulsification within the gastric lumen it is necessary to measure the degree of emulsification in vivo. The measurement of emulsification is also important in the food industry and in other areas. NMR has bee...

BACKGROUND Magnetic resonance imaging (MRI) is a useful tool to study brain growth and organization in preterm neonates for clinical and research purposes, but its practicality can be limited by time and medical constraints. The aim of this study was to determine if MRI relaxometry of the deep nuclei, as opposed to white matter, would reflect the influence of gestational age at birth on structu...

PURPOSE This study aims to increase the precision of single-compartment DESPOT relaxometry by two means: (i) a joint system relaxometry (JSR) approach that estimates parameters in a single step using all available data; and (ii) optimizing acquisition parameters by deploying a robust design tool based on the Crámer-Rao lower bound (CRLB). METHODS Following the development of the analysis and ...

The volume fraction of water related to myelin (fmy) is a promising MRI index for in vivo assessment of brain myelination, that can be derived from multi-component analysis of T1 and T2 relaxometry signals. However, existing quantification methods require rather long acquisition and/or post-processing times, making implementation difficult both in research studies on healthy unsedated children ...

Introduction and Motivation. In osteoarthritis of the knee (knee OA), different morphological, molecular, and biochemical biomarkers for predicting or evaluating the degree of knee OA have been investigated. It has been observed that with progression of knee OA morphometric parameters such as cartilage thickness and volume decrease; and that molecular and biochemical cartilage properties such a...