BACKGROUND Myocardial fibrosis is a common hallmark of many diseases of the heart. Late gadolinium enhanced MRI is a powerful tool to image replacement fibrosis after myocardial infarction (MI). Interstitial fibrosis can be assessed indirectly from an extracellular volume fraction measurement using contrast-enhanced T1 mapping. Detection of short T2* species resulting from fibrotic tissue may p...

Introduction: Quantitative T2 (qT2) enables scientists to discern tissue microcompartments by measuring multiple T2 decays using a multiecho acquisition [1]. This technique is sensitive to myelin content [2] and has uncovered previously undetected microcompartments in MS and PKU pathological tissue [3]. We show that traditional qT2 analysis using a smoothing constraint underestimates the myelin...

Cortical subpial demyelination is frequent in multiple sclerosis (MS) and is closely associated with disease progression and poor neurological outcome. Although cortical lesions have been difficult to detect using conventional MRI, preliminary data using T2*-weighted imaging at ultra-high field 7T MRI showed improved sensitivity for detecting and categorizing different histological types of cor...

This paper proposes a method for local deformation analysis of the heart's left ventricle (LV) which is of an utmost interest in characterizing the myocardium disease extent and severity. Our method is based on regional curvature variation calculation using the Hotelling T2 two samples difference metric. Our approach is validated on real data obtained from myocardial scintigraphy imaging techni...

OBJECTIVES Non-small cell lung cancer (NSCLC) invading the visceral pleura is classified as T2 stage, and NSCLC invading the chest wall, diaphragm, phrenic nerve, mediastinal pleura or parietal pleura is classified as T3. But, there is no definition as to whether tumours directly invading an adjacent lobe beyond the fissure should be classified as T2 or T3. We assessed whether these tumours sho...