OBJECTIVES The aim of this study was to determine changes in axillary artery diameter and peak systolic velocity in asymptomatic individuals during upper limb positioning commonly used to assess vascular pathology in athletes. DESIGN Repeated measures observational study. SETTING Physiology laboratory. PARTICIPANTS Subjective and objective screening excluded individuals with past, or pres...

Vinculin (Vcl) plays a key structural role in ventricular myocytes that, when disrupted, can lead to contractile dysfunction and dilated cardiomyopathy. To investigate the role of Vcl in myocyte and myocardial function, cardiomyocyte-specific Vcl knockout mice (cVclKO) and littermate control wild-type mice were studied with transmission electron microscopy (TEM) and in vivo magnetic resonance i...

The influence of supine rest on the blood pressure response to standing and 70 degrees head-up tilt was studied in detail for the first 30 s after the change of posture. Following 20 min of supine rest, the active transition to standing was accompanied by an immediate increase in systolic pressure of 29 +/- 6 mmHg (mean +/- SEM). This was followed by large fluctuations in systolic pressure: to ...

In intact chronically instrumented dogs, left ventricular dynamics were studied during cardiopulmonary resuscitation (CPR). Electromagnetic flow probes measured cardiac output and coronary blood flow, ultrasonic transducers measured cardiac dimensions, and micromanometers measured left ventricular, right ventricular, aortic, and intrathoracic pressures. The dogs were anesthetized with morphine,...

DESCRIPTION A 24-year-old man presented with dyspnoea on exertion. Chest x-ray showed an enlargement of the upper anterior mediastinum (figure 1A). Chest CT showed a huge mass with the size of 7.6×4.8 cm in the upper anterior mediastinum (figure 1B). This mass compressed the main pulmonary artery trunk (MPA) and the left pulmonary artery. Transthoracic two-dimensional echocardiography also reve...

UNLABELLED The use of an inspiratory impedance threshold valve (ITV) during active compression-decompression (ACD) cardiopulmonary resuscitation (CPR) improves perfusion pressures, and vital organ blood flow. We evaluated the effects of positive end-expiratory pressure (PEEP) on gas exchange, and coronary perfusion pressure gradients during ACD + ITV CPR in a porcine cardiac arrest model. All a...

objective(s):the aim of this study was to improve flowability and compressibility characteristics of starch to use as a suitable excipient in direct compression tabletting. quasi-emulsion solvent diffusion was used as a crystal modification method. materials and methods: corn starch was dissolved in hydrochloric acid at 80˚c and then ethanol as a non-solvent was added with lowering temperature ...

hereby we report a patient with thalassemia major having extradural cord compression at t3-t9 levels due to a mass of extramedullary hematopoiesis (emh) tissue, whose treatment was successful with hypertransfusion therapy alone. the patient was a 23-year-old man who had not received regular blood transfusion since two years before admission. he suffered from paraparesis with a history of progre...

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