Increasing health care costs mandate a shift in our thinking about health and disease from treatment to prevention. Effective prevention requires that we improve our abilities to predict and personalize health and disease risks. The article proposes that systems biology will play an essential role in personalized health assessments.

Partial correlation analysis of genomic data 2 ABSTRACT Motivation: A major challenge of systems biology is to infer biochemical interactions from large-scale

Discovering the causal mechanisms of biological systems is necessary to design new drugs and therapies. Computational Causal Discovery (CD) is a field that offers the potential to discover causal relations and causal models under certain conditions with a limited set of interventions / manipulations. This chapter reviews the basic concepts and principles of CD, the nature of the assumptions to ...

Systems biology can provide unique insights into molecular evolution, but most existing work in this domain uses one-off methods and tools. In this paper, we advocate development of generic frameworks for evolutionary systems biology and discuss in some detail key characteristics it should possess to be most applicable and useful. We offer one such framework ourselves, and evaluate it with a ca...