objective(s): systemic lupus erythematosus (sle) is a multi-factorial autoimmune disease which may be characterized by t lymphocytes dysfunctions. th17 cells have been identified as new effector cells, which play an important role in the pathogenesis. in recent years, immunomodulatory effect of vitamin d3 has been noticed. in the present experiment, the effect of vitamin d3 on the expression of...

isolated hematuria and its association with proteinuria, and urinary cast and systemic lupus erythematosus (sle) disease activity, and decision for renal biopsy is a dilemma for physician in sle patients. the aim of this study was to investigate 1. whether isolated hematuria is associated with active sle, 2. to determine duration between hematuria and proteinuria and urinary cast, and 3. to det...

aim and background: systemic lupus erythematosus (sle) is a chronic autoimmune disease usually associated with high levels of pain and impairment in different systems, producing high levels of stress in patients who suffer from it. the purpose of this study was to consider the effectiveness of cognitive-behavioral stress management (cbsm) therapy on stress of female patients with sle. methods a...

background: diagnosis and treatment of neuropsychiatric lupus is still a major challenge in clinical practice. we investigated the association between depression and anti-ribosomal p (anti-p) antibodies in a sample of iranian patients with systemic lupus erythematosus (sle). materials and methods: th is cross-sectional study was conducted on adult patients with sle referring to a referral out-p...

a 21 years old woman presented with a history of sle and skin lesions on the arms, trunk, and abdomen. the left gluteal region was ulcerated and painful and occasionally extruded a chalky white material. the patient referred from rheumatology department for osteomyelitis assessment. on physical examination the patient had hard, nontender lesions on the proximal arms, lower abdomen and lower bac...

objective: hla-g is a nonclassical major histocompatibility complex antigen and is expressed as seven isoforms, including four membrane bound (hla-g1 to –g4) and three soluble (hla-g5 to –g7) forms. the pattern of selective expression of hla-g transcripts in tissues shows the existence of a tight transcriptional control on the gene expression. it has been revealed that cytokines including inter...

background and objectives: this research study was conducted to determine the correlation between the clinicopathologic features and the outcome of membranous nephropathy. materials and methods: data were retrospectively reviewed from all patients with a diagnosis of membranous nephropathy. demographic, initial laboratory, and clinical findings were collected and the biopsy specimens were revie...

background systemic lupus erythematosus (sle) is an autoimmune connective-tissue disease involving multiple organs and systems. some evidence has demonstrated that disease activity could be associated with increased risk of organ damage. objectives the aim of this study was to determine the association between systemic lupus erythematosus disease activity index (sledai) scores and subclinical c...

introduction: systemic lupus erythematosus (sle) is an autoimmune disease affect nearly every organ system. pulmonary involvement, which is a common manifestation of sle, can remain undiagnosed if asymptomatic. this study aimed to evaluate the efficiency of spirometric findings in early detection of silent pulmonary involvement and examine its correlation with the six minute walk test in sle pa...

introduction systemic lupus erythematosus (sle) is a complex autoimmune and inflammatory disease. many studies show hla alleles can be associated with sle. the aim of this study was to determine the association of hla-drb1 alleles with juvenile- onset in iranian children. materials and methods at a case – control study, 31 children with systemic lupus erythematosus (case group) who referred to ...