BACKGROUND Newly formed platelets are associated with increased aggregation and adverse outcomes in patients with coronary artery disease (CAD). The mechanisms involved in the regulation of platelet turnover in patients with CAD are largely unknown. AIM To investigate associations between platelet turnover parameters, thrombopoietin and markers of low-grade inflammation in patients with stabl...

BACKGROUND In a collaboration between the Canadian Laboratory Initiative on Pediatric Reference Intervals (CALIPER) and the Canadian Health Measures Survey (CHMS), we determined reference value distributions using an a priori approach and created a comprehensive database of age- and sex-stratified reference intervals for clinically relevant hematologic parameters in a large household population...

The results of laboratory tests have little practical utility unless clinical studies have ascribed various states of health and disease to intervals of values. Several factors affect hematologic values, including race, environment, time of sampling, test method, blood collection site, gestational age and maternal factors. Since these factors vary in various populations, they can cause differen...

The functional activity of von Willebrand factor (VWF) is most frequently measured by using the ristocetin cofactor assay (VWF:RCo). However, the method's drawbacks include unsatisfactory precision, sensitivity and availability of automated system applications. We have developed an alternative assay (INNOVANCE VWF Ac) that is based on the binding of VWF to recombinant glycoprotein Ib (GPIb). Tw...

The lamellar body count (LBC) represents an alternative method to the TDx-FLM II (Abbott Laboratories, Abbott Park, IL), which is planned to be discontinued, for assessing fetal lung maturity. Our objective was to validate the LBC on 3 hematology analyzers (Coulter LH 750 and Coulter Ac.T diff2, Beckman Coulter, Brea, CA; and Sysmex XE-2100, Sysmex, Mundelein, IL) to serve as a template for oth...

Background: COVID-19 is still present in the world, though extent varies by region and country. According to World Health Organization, there have been over 617 million confirmed cases of 13 deaths worldwide since pandemic began on March 10, 2023. Aims Objectives: This a study conducted with aim providing biomarkers predict disease progression mortality based red cell indices platelet which are...

BACKGROUND Attempts to analyze bone marrow aspirates have been reported with the use of several automated blood cell counters, but sufficient accuracy in examination is not acquired yet. Major problems have included difficulties in correctly differentiating various immature cells and interference by lipid in bone marrow aspirates. The goal of this study was to solve these problems to attain mor...

OBJECTIVE To analyze the expression of various antigens on the leukemic blasts and to determine the hematological parameters, in Acute Lymphoblastic Leukemia (ALL) patients at presentation. STUDY DESIGN Observational study. PLACE AND DURATION OF STUDY King Edward Medical University, Lahore and Hameed Latif Hospital, Lahore, from February 2013 to March 2014. METHODOLOGY A total of 50 newly...

BACKGROUND The speed and quality of information have become essential items in the release of laboratory reports. The Sysmex(®)SP1000-I device has been developed to prepare and stain smear slides. However, for a device to be cleared for use in the laboratory routine it must pass through a validation process. OBJECTIVE To evaluate the performance and reliability of the Sysmex(®) SP-1000i slide...