The effect of elevated temperature on cytotoxicity of rhodamine 123 (R123) was tested in vitro on B16 mouse melanoma cells. Simultaneous 1-h exposure to R123 and hyperthermia (43 degrees C for 1 h) resulted in marked enhancement of R123 cytotoxicity. Thermal enhancement of R123 cytotoxicity occurred at temperatures as low as 38 degrees C. Heat treatment (43 degrees C for 1 h) given immediately ...

Intoroduction Prodrug approach deals with chemical biotransformation or enzymatic conversion or involves inactive or less active bio-reversible derivatives of active drug molecules. They have to pass through enzymatic or chemical biotransformation before eliciting their pharmacological action. Methods & Materials The two different pharmacophores combine to give synergistic activity or may hel...

Herein, we report the development of multiphase epoxy-based nanocomposite blends with enhanced fracture toughness and controlled microstructure. The are based on bifunctional tetrafunctional epoxy resins, suitable for a wide range applications particularly as matrices advanced high temperature fibre reinforced composites glass transition temperatures exceeding 200° Celsius. comprise nanoscale (...

The potential of photocatalysts modified cement-based materials in degrading environmental pollutants is evident previous studies, but the application photocatalytic still appears limited actual practice due to dispersion effect. This work seeks prepare cement paste by mixing with BiOBr precursor solutions terms improvement efficiency, and additional hydrothermal conditions provided autoclaved ...

Kinetic studies were done to obtain a quantitative estimation of the synergistic interactions that occur between phosphoenolpyruvate carboxylase (orthophosphate:oxaloacetate carboxylase (phosphorylating) E.C. 4.1.1.31) from Escherichia coli K12 and various combinations of its primary substrate, P-enolpyruvate, and the activators acetylcoenzyme A, CDP, GTP, and fructose 1,6-bisphosphate. The ana...